Tubular and interstitial proteases as regulators of the epithelial sodium channel (ENaC) (A04)

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The appropriate regulation of the epithelial sodium channel (ENaC) in the distal nephron is essential for the fine-tuning of renal sodium excretion. In addition to tubular proteases activating ENaC by proteolytic channel cleavage, interstitial proteases may modulate ENaC activity by activating the basolateral protease-activated receptor type 2 (PAR2). This project combines electrophysiological and molecular biological methods to identify tubular proteases relevant for proteolytic ENaC activation and to investigate the molecular mechanisms involved. Moreover, the underlying mechanisms and signaling pathways of PAR2-mediated ENaC regulation by interstitial proteases will be elucidated.