EFFECT OF PROTEASES AND CONTRACTILITY ON CAPILLARY MORPHOGENESIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 内皮细胞和不同类型的间质细胞在不同密度的纤维蛋白凝胶中共培养。间质细胞向内皮细胞提供促血管生成信号，内皮细胞通过形成毛细血管的过程做出反应。这一过程可以通过两种机制发生，根据培养条件的不同，血管生成或血管生成。我们感兴趣的是调节细胞收缩性质或基质降解的蛋白质的作用，以及它们对毛细血管形态发生的正常过程有什么影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Endothelial cells and different types of interstitial cells are cocultured within fibrin gels of different densities. The interstitial cells provide proangiogenic signals to the endothelial cells which respond by undergoing a process to form capillaries. This process can occur via two mechanisms, vasculogenesis or angiogenesis depending on the culture conditions. We are interested in the role of proteins which regulate the contractile nature of the cells or matrix degradation and what effects they have on the normal process of capillary morphogenesis.