Assessment of the structure and function of the renal interstitium by intravital multiphoton microscopy (B02)

通过活体多光子显微镜评估肾间质的结构和功能（B02）

• 批准号: 415849476
• 金额: --
• 依托单位: Institut für Physiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/415849476?language=en
• 关键词: Assessment; structure; function; renal; interstitium

Little is known about the physiology of the renal interstitial compartment and how it might interfere with tubular and vascular functions. This project will address these questions using serial intravital multiphoton microscopy, which will allow us to visualize the dynamic changes of the composition of renal interstitial cells in real time and to study interstitial-tubular/vascular communication and its effect on renal function. Our previous findings indicate that interstitial cells are motile. In the context of a potential renal interstitial stem cell nice, we will further clarify the role of interstitial cell mobility in renal regeneration.

关于肾间质室的生理学以及它如何干扰小管和血管功能，我们所知甚少。本项目将使用连续活体多光子显微镜来解决这些问题，这将使我们能够实时可视化肾间质细胞组成的动态变化，并研究间质-小管/血管通讯及其对肾功能的影响。我们之前的研究结果表明间质细胞具有运动性。在潜在的肾间质干细胞nice的背景下，我们将进一步阐明间质细胞运动在肾再生中的作用。