Assessment of the structure and function of the renal interstitium by intravital multiphoton microscopy (B02)

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Little is known about the physiology of the renal interstitial compartment and how it might interfere with tubular and vascular functions. This project will address these questions using serial intravital multiphoton microscopy, which will allow us to visualize the dynamic changes of the composition of renal interstitial cells in real time and to study interstitial-tubular/vascular communication and its effect on renal function. Our previous findings indicate that interstitial cells are motile. In the context of a potential renal interstitial stem cell nice, we will further clarify the role of interstitial cell mobility in renal regeneration.