Relevance of inflammation and fibrosis for renal regeneration (B04)

炎症和纤维化与肾再生的相关性 (B04)

• 批准号: 415852565
• 金额: --
• 依托单位: Klinik und Poliklinik für Innere Medizin II
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/415852565?language=en
• 关键词: Relevance; inflammation; fibrosis; renal; regeneration

Kidneys have an impressive, yet incomplete capability to regenerate after acute insults. The aim of our project is to better understand how the immune response and specific subsets of inflammatory cells as well as specific “types” of fibrosis generated by different types of collagen-producing cells support or impede regeneration of renal structures, recovery of renal function, and regression of fibrosis. We will use reversible unilateral ureteral obstruction and adenine feeding to model acute renal insults and to follow regeneration.

肾脏有一个令人印象深刻的，但不完全的能力，再生后，急性损伤。我们项目的目的是更好地了解免疫反应和炎症细胞的特定亚群以及由不同类型的胶原蛋白产生细胞产生的特定“类型”的纤维化如何支持或阻碍肾结构的再生，肾功能的恢复和纤维化的消退。我们将使用可逆性单侧输尿管梗阻和腺嘌呤喂养来模拟急性肾损伤并跟踪再生。