Fibronectin and its role in polycystic kidney diseases (B03)

纤连蛋白及其在多囊肾病中的作用（B03）

• 批准号: 415850522
• 金额: --
• 依托单位: Medizinische Klinik 4 - Nephrologie und Hypertensiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/415850522?language=en
• 关键词: Fibronectin; its; role; polycystic; kidney

The project will investigate the question if the glycoprotein fibronectin, an extracellular matrix constituent, plays an essential role for the prevention of polycystic kidney disease (PKD). This hypothesis is based on preliminary findings indicating that the induced deletion of fibronectin in newborn mice results in the formation of corticomedullary kidney cysts and the loss of kidney integrity and function. We will characterize the molecular mechanisms that lead to cyst formation following fibronectin deletion in the mouse and expect that the findings will contribute to our understanding of the molecular pathogenetic events that are behind PKD in humans.

该项目将研究糖蛋白纤连蛋白（一种细胞外基质成分）是否在预防多囊肾病（PKD）中发挥重要作用。这一假设基于初步发现，表明新生小鼠中纤连蛋白的诱导缺失会导致皮质髓质肾囊肿的形成以及肾脏完整性和功能的丧失。我们将描述小鼠纤连蛋白缺失后导致囊肿形成的分子机制，并期望这些发现将有助于我们理解人类 PKD 背后的分子发病机制。