Epigenetic identity and plasticity of renal tubular and interstitial cells (C05)

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Disturbances in the homeostasis of kidney function, e.g. driven by hypoxic insults in acute or chronic kidney diseases, may lead to an epigenetic re-programing of transcriptional responses and cellular function. Hypoxia-inducible transcription factors (HIF) dictate expression of genes which are directly involved in modifying DNA or histone proteins, and activity of some of the chromatin modifying enzymes is dependent on the presence of oxygen. This project assesses the influence of hypoxia and HIF-stabilization on epigenetic factors in the normal kidney as well as during acute kidney injury.