Cognitive Resilience among Older Samoans

老年萨摩亚人的认知弹性

基本信息

  • 批准号:
    10608940
  • 负责人:
  • 金额:
    $ 81.65万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-03-01 至 2026-02-28
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Older Samoans are a unique population for gaining knowledge about cognitive resilience. Dementia has been reported as occurring at low rates among them. Further, our recent pilot data from Independent Samoa found that although there was variability in their memory scores, older Samoans had scores that did not significantly differ from younger Samoans. The proposed study will examine factors that might contribute to this cognitive resilience: (a) unique positive age beliefs that predominate in Samoan culture; and (b) the recently identified CREBRF gene variant (rs373863828) that occurs in 45% of Samoans, but in less than 1% of non- Samoans. Previous research supports our premise that these cultural and genetic factors will contribute to cognitive resilience. The Principal Investigator conducted the first studies to demonstrate that culture-based positive age beliefs predict lower stress and better aging cognitive health, including lower risk of developing Alzheimer’s- disease biomarkers and dementia. This age belief-cognition finding has been supported by three meta-analyses, but has not been studied among Samoans. Additionally, our pilot data with older persons living in Independent Samoa showed the CREBRF gene variant predicted significantly better cognitive scores, and previous studies have shown this gene variant is associated with lower levels of type 2 diabetes and fasting blood glucose, both of which are associated with lower dementia risk. Further, the gene variant is part of a larger mechanism, present in everyone, that leads to the development of brain neuroplasticity. Because favorable environmental factors can increase this neuroplasticity, positive age beliefs (which tend to be assimilated from culture) may stimulate the neuroplasticity property of the CREBRF gene variant. Thus, our Specific Aims, which will be carried out for the first time, are to examine whether aging cognitive resilience is predicted by: (a) greater adherence to the prevailing positive Samoan aging beliefs; (b) the CREBRF gene variant; (c) a synergistic interaction of positive age beliefs and the gene variant; and (d) structural- level factors (i.e., Westernization, ageism and usefulness to others) as well as individual-level factors (i.e., ethnic identity and self-relevance of age beliefs) acting as moderators of a gene-culture interaction. We will assess the CREBRF gene variant and age beliefs at baseline, and cognitive resilience across three years, among 750 Samoans, aged 60 and older. We will recruit one third from each of the following (in ascending order of Westernization): Independent Samoa, American Samoa and San Francisco, CA. The proposed research has the potential to benefit cognitive aging health because it could identify a set of modifiable age beliefs and moderators for interventions and identify a new biological pathway to cognitive resilience in all older persons.
项目摘要 老年萨摩亚人是获得认知复原力知识的独特人群。痴呆 据报道,在这些国家中发生率很低。此外,我们最近从独立萨摩亚获得的试验数据表明, 研究发现,尽管老年萨摩亚人的记忆力得分存在差异,但老年萨摩亚人的记忆力得分并不存在差异。 与年轻的萨摩亚人有很大不同。拟议的研究将审查可能导致这一情况的因素 认知弹性:(a)萨摩亚文化中占主导地位的独特积极的年龄观念;(B)最近 确定了CREBRF基因变异(rs373863828),发生在45%的萨摩亚人中,但在不到1%的非萨摩亚人中, 萨摩亚人 以前的研究支持我们的假设,这些文化和遗传因素将有助于认知 resilience.主要研究者进行了第一项研究,以证明基于培养的阳性年龄 信仰预测较低的压力和更好的老化认知健康,包括较低的风险发展阿尔茨海默氏症- 疾病生物标志物和痴呆症。这一年龄信念-认知发现得到了三项荟萃分析的支持, 但还没有在萨摩亚人中进行过研究。此外,我们的试点数据与老年人生活在独立 萨摩亚的研究表明,CREBRF基因变异体可以预测出更好的认知得分, 已经表明这种基因变异与2型糖尿病和空腹血糖水平较低有关, 与较低的痴呆风险有关。此外,基因变异是一个更大机制的一部分,存在于 每个人,这导致大脑神经可塑性的发展。因为有利的环境因素可以 增加这种神经可塑性,积极的年龄信念(往往是从文化中吸收)可能会刺激 CREBRF基因变体的神经可塑性。 因此,我们的具体目标,这将是第一次进行,是检查是否老化的认知 弹性预测:(a)更大的坚持普遍的积极萨摩亚老龄化的信念;(B) CREBRF基因变体;(c)积极年龄信念和基因变体的协同相互作用;和(d)结构性- 水平因子(即,西化、年龄歧视和对他人有用)以及个人层面的因素(即,民族 身份和年龄信念的自我相关性)作为基因-文化相互作用的调节者。 我们将评估CREBRF基因变异和基线年龄信念,以及三个年龄段的认知弹性。 在750名60岁以上的萨摩亚人中,我们将从以下每个人中招募三分之一(在提升中 西方化的顺序):独立萨摩亚,美属萨摩亚和加利福尼亚州的旧金山弗朗西斯科。 这项拟议中的研究有可能有益于认知老化健康,因为它可以确定一组 可修改的年龄信念和干预的主持人,并确定一个新的生物途径,以认知 所有老年人的复原力。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

BECCA R LEVY其他文献

BECCA R LEVY的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('BECCA R LEVY', 18)}}的其他基金

Cognitive Resilience among Older Samoans
老年萨摩亚人的认知弹性
  • 批准号:
    10360521
  • 财政年份:
    2021
  • 资助金额:
    $ 81.65万
  • 项目类别:
Administrative Supplement to Cognitive Resilience among Older Samoans
老年萨摩亚人认知弹性的行政补充
  • 批准号:
    10773593
  • 财政年份:
    2021
  • 资助金额:
    $ 81.65万
  • 项目类别:
Stress Biomarkers as a Potential Link Between Age Beliefs and Health
压力生物标志物是年龄信念与健康之间的潜在联系
  • 批准号:
    8697840
  • 财政年份:
    2014
  • 资助金额:
    $ 81.65万
  • 项目类别:
Stress Biomarkers as a Potential Link Between Age Beliefs and Health
压力生物标志物是年龄信念与健康之间的潜在联系
  • 批准号:
    8929104
  • 财政年份:
    2014
  • 资助金额:
    $ 81.65万
  • 项目类别:
Culture-Gene Relationship: A Novel Model of Aging Cognitive Health
文化与基因的关系:老龄化认知健康的新模型
  • 批准号:
    9311065
  • 财政年份:
    2009
  • 资助金额:
    $ 81.65万
  • 项目类别:
Positive Age Stereotypes Across the LifeSpan
整个生命周期中积极的年龄刻板印象
  • 批准号:
    7649694
  • 财政年份:
    2009
  • 资助金额:
    $ 81.65万
  • 项目类别:
Positive Age Stereotypes Across the LifeSpan
整个生命周期中积极的年龄刻板印象
  • 批准号:
    7896773
  • 财政年份:
    2009
  • 资助金额:
    $ 81.65万
  • 项目类别:
Racial Disparities in Heart Attack Recovery: Role of Stress and Stigma
心脏病康复中的种族差异:压力和耻辱的作用
  • 批准号:
    7880003
  • 财政年份:
    2008
  • 资助金额:
    $ 81.65万
  • 项目类别:
Racial Disparities in Heart Attack Recovery: Role of Stress and Stigma
心脏病康复中的种族差异:压力和耻辱的作用
  • 批准号:
    7464360
  • 财政年份:
    2008
  • 资助金额:
    $ 81.65万
  • 项目类别:
Racial Disparities in Heart Attack Recovery: Role of Stress and Stigma
心脏病康复中的种族差异:压力和耻辱的作用
  • 批准号:
    8102893
  • 财政年份:
    2008
  • 资助金额:
    $ 81.65万
  • 项目类别:

相似海外基金

An innovative, AI-driven prehabilitation platform that increases adherence, enhances post-treatment outcomes by at least 50%, and provides cost savings of 95%.
%20创新、%20AI驱动%20康复%20平台%20%20增加%20依从性、%20增强%20治疗后%20结果%20by%20at%20至少%2050%、%20和%20提供%20成本%20节省%20of%2095%
  • 批准号:
    10057526
  • 财政年份:
    2023
  • 资助金额:
    $ 81.65万
  • 项目类别:
    Grant for R&D
Improving Repositioning Adherence in Home Care: Supporting Pressure Injury Care and Prevention
提高家庭护理中的重新定位依从性:支持压力损伤护理和预防
  • 批准号:
    490105
  • 财政年份:
    2023
  • 资助金额:
    $ 81.65万
  • 项目类别:
    Operating Grants
I-Corps: Medication Adherence System
I-Corps:药物依从性系统
  • 批准号:
    2325465
  • 财政年份:
    2023
  • 资助金额:
    $ 81.65万
  • 项目类别:
    Standard Grant
Unintrusive Pediatric Logging Orthotic Adherence Device: UPLOAD
非侵入式儿科记录矫形器粘附装置:上传
  • 批准号:
    10821172
  • 财政年份:
    2023
  • 资助金额:
    $ 81.65万
  • 项目类别:
Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples with Implications for Alzheimer’s Disease Risk
Nuestro Sueno:夫妻干预措施的文化适应,以改善拉丁裔夫妇的 PAP 依从性和睡眠健康,对阿尔茨海默病风险产生影响
  • 批准号:
    10766947
  • 财政年份:
    2023
  • 资助金额:
    $ 81.65万
  • 项目类别:
CO-LEADER: Intervention to Improve Patient-Provider Communication and Medication Adherence among Patients with Systemic Lupus Erythematosus
共同领导者:改善系统性红斑狼疮患者的医患沟通和药物依从性的干预措施
  • 批准号:
    10772887
  • 财政年份:
    2023
  • 资助金额:
    $ 81.65万
  • 项目类别:
Pharmacy-led Transitions of Care Intervention to Address System-Level Barriers and Improve Medication Adherence in Socioeconomically Disadvantaged Populations
药房主导的护理干预转型,以解决系统层面的障碍并提高社会经济弱势群体的药物依从性
  • 批准号:
    10594350
  • 财政年份:
    2023
  • 资助金额:
    $ 81.65万
  • 项目类别:
Antiretroviral therapy adherence and exploratory proteomics in virally suppressed people with HIV and stroke
病毒抑制的艾滋病毒和中风患者的抗逆转录病毒治疗依从性和探索性蛋白质组学
  • 批准号:
    10748465
  • 财政年份:
    2023
  • 资助金额:
    $ 81.65万
  • 项目类别:
Improving medication adherence and disease control for patients with multimorbidity: the role of price transparency tools
提高多病患者的药物依从性和疾病控制:价格透明度工具的作用
  • 批准号:
    10591441
  • 财政年份:
    2023
  • 资助金额:
    $ 81.65万
  • 项目类别:
Development and implementation of peer-facilitated decision-making and referral support to increase uptake and adherence to HIV pre-exposure prophylaxis in African Caribbean and Black communities in Ontario
制定和实施同行协助决策和转介支持,以提高非洲加勒比地区和安大略省黑人社区对艾滋病毒暴露前预防的接受和依从性
  • 批准号:
    491109
  • 财政年份:
    2023
  • 资助金额:
    $ 81.65万
  • 项目类别:
    Fellowship Programs
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了