Design, synthesis and photophysics of metal-doped nucleic acids

金属掺杂核酸的设计、合成和光物理学

• 批准号: 417637295
• 负责人: Professor Dr. Jens Müller
• 金额: --
• 依托单位: Institut für Anorganische und Analytische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/417637295?language=en
• 关键词: Design; synthesis; photophysics; metal; doped

In this project, nucleic acids with metal-based luminescence will be synthesized and characterized. In doing so, their photofunctionality will be investigated, opening up the opportunity for subsequent potential applications in biomedicine and functional microscopy. Towards this end, ligand-based nucleoside analogs will be synthesized, reacted with suitable transition metal complexes and incorporated into oligonucleotides by using automated solid phase synthesis. In addition, proximally (via the coordination plane) and distally (via an ancillary ligand) intercalating metal complexes will be synthesized and investigated. The doped nucleic acids obtained via these three strategies are ideally suited for an investigation of fundamental photophysical properties of polynuclear luminescent metal complexes.

在这个项目中，将合成和表征具有金属基发光的核酸。在此过程中，将研究它们的光功能性，为随后在生物医学和功能显微镜中的潜在应用开辟机会。为此，将合成基于配体的核苷类似物，与合适的过渡金属络合物反应，并通过使用自动化固相合成掺入寡核苷酸中。此外，近端（通过配位平面）和远端（通过辅助配体）嵌入金属配合物将被合成和研究。通过这三种策略获得的掺杂核酸非常适合于多核发光金属配合物的基本电子物理性质的调查。