Dilating renal medullary microvessels by the NO-sGC-cGMP pathway for renoprotection (A02)

我们通过评估sGC在体外缺氧/复氧和体外缺血/再灌流后的功能能力，阐明sGC激活在急性肾损伤和慢性肾脏疾病中的保护作用。对供应肾脏损伤危险区域的微血管的功能研究是独一无二的。结合肾脏血流灌注和自动调节的测量以及基于MR的肾脏氧合成像，是表征基于物质的、血管靶向的肾脏保护的一种独特的方法。包含人类髓质微血管可以将药理作用转化为人体环境。

We set out to elucidate the protective role of sGC-activation in acute kidney injury and in developing chronic kidney disease by assessing the functional capacity of sGC under hypoxia/re-oxygenation in vitro and after ischemia/re-perfusion ex vivo. Functional investigations on microvessels that supply the area-at-risk for kidney damage performed here are unique. Combining measurements of renal perfusion and autoregulation as well as MR based imaging of renal oxygenation represents a distinctive approach for characterizing substance based, vessel-targeted, renal protection. Inclusion of human medullary microvessels allows translating pharmacological effects into the human setting.