The role of primary metabolites in the intestinal ecosystem under normal and inflamed conditions (P08)

正常和炎症条件下初级代谢物在肠道生态系统中的作用（P08）

• 批准号: 418402268
• 金额: --
• 依托单位: Max-von-Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/418402268?language=en
• 关键词: role; primary; metabolites; intestinal; ecosystem

Inflammatory processes create metabolic and trophic niches in the gut which, in turn, affect the composition and function of the microbial ecosystem. Project P08 will investigate the role of primary luminal metabolites, specifically organic acids and polyamines and characterize the impact of sensing, uptake and metabolic interactions on the fitness and growth of disease-relevant Salmonella, Desulfovibrio, Enterococcus and the individual species of the microbiota. Analyses will be done in vitro and in gnotobiotic mice colonized with the minimal bacterial consortium Oligo-MM and other mouse models of gut inflammation.

炎症过程在肠道中产生代谢和营养生态位，这反过来又影响微生物生态系统的组成和功能。项目P08将研究初级管腔代谢物的作用，特别是有机酸和多胺，并表征传感，摄取和代谢相互作用对疾病相关沙门氏菌，脱硫弧菌，肠球菌和微生物群的个体物种的适应性和生长的影响。分析将在体外和用最小细菌聚生体Oligo-MM定殖的无菌小鼠和其他肠道炎症小鼠模型中进行。