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苔類ツボミゴケ属の化学成分および生理活性物質の探索

壶菌属苔藓化学成分和生理活性物质的研究

基本信息

批准号：
09771933
负责人：
長島史裕
金额：
$ 1.34万
依托单位：
Tokushima Bunri University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Encouragement of Young Scientists (A)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

项目摘要

前年度に引き続きツボミゴケ属苔類について,またツボミゴケ属以外のヨーロッパ産苔類についても成分研究を行った.それぞれの有機溶媒抽出物の各種クロマトグラフィーを行うことにより,各成分を単離,精製した.また単離が困難なフラクションについては,申請,購入した紫外可視分光検出器を付随した高速液体クロマトグラフィーにより精製した.その結果,オオホウキゴケから新規パーオキシクパラン型セスキテルペノイド,新規パーオキシラブダン型および新規セコラブダン型ジテルペノイドを,その他に多数の既知化合物をそれぞれ単離した.新規化合物の相対構造は,主としてNMR解析を行うことにより決定した.しかし,相対立体構造の決定が困難であり,幸運にも結晶化した化合物についてはX線結晶解析により決定した.また,絶対構造未知の化合物については,CDスペクトルの測定,絶対既知化合物への化学誘導,あるいはX線結晶解析を行うことにより決定した.また,ツボミゴケ属以外の数種のヨーロッパ産苔類からも新規セスキおよびジテルペノイドと既知セスキおよびジテルペノイドを単離,構造決定した.今回のツボミゴケ属苔類の研究の結果とこれまでに行ってきた研究の成果とを併せ考えると,同族同種であっても地理的差異による化学成分の違いがあることをさらに裏付ける結果を得た.また,新規ラブダン型ジテルベンやパーオキシクパラン型セスキテルペンは,生合成課程を考える上で興味ある化合物であると考える.また,ヨーロッパ産苔類からの新規化合物の単離,構造決定は,これまでに行ってきた苔類の化学成分研究の資料の一部として新たな知見を得ることができた.今回,単離,構造決定した化合物の一部は,他の研究機関に依頼して活性試験をおこなったところ,数種の化合物にMMP阻害活性が弱いながらも見られ,また抗HIV活性,トポイソメラーゼ活性についても現在検討中である.

In the previous year, the genus Lepidoptera was introduced as a genus of liverwort, while the composition of the genus outside the genus was studied. All kinds of organic solvent extractives are used in the production of organic solvents, and all kinds of organic solvents are separated and refined. You need to apply for the UV spectroscopic spectrometer to pay for the high-speed liquid equipment. The results showed that most of the known compounds were isolated from each other, and most of the known compounds were isolated. The new compounds have been fabricated, and the main NMR analysis line has been determined. The X-ray diffraction analysis of the X-ray diffraction of the compound is determined by the crystal analysis of the X-ray diffraction X-ray diffraction. The unknown compounds were determined by CD, the known compounds were analyzed by chemical chemistry, and the X-ray diffraction was analyzed by X-ray diffraction. There are several kinds of food in other countries outside the genus. New regulations of the genus lichen. Do not know that they do not. Do not know that they do not. The results of this study on liverworts belong to the species of liverwort. the results of the studies on the results of this study have been reviewed, and the results of the differential chemical components of geography of the same family have been successful. In this paper, new rules and regulations are introduced, and the results are as follows: (1) in the process of synthesis, there are some compounds in the synthetic process. The chemical constituents of liverworts were isolated, determined, and studied. Information on the chemical composition of liverworts was obtained. This time, it was determined that one of the compounds was isolated, and the other research mechanism was based on the activity of the compound, the activity of several compounds, the MMP inhibitory activity, the weak activity, the anti-HIV activity, the anti-HIV activity, the anti-DNA activity, the enzyme activity.