Origin and functional implication of coronary endothelium heterogeneity in development and post-injury adaption (B06)

冠状动脉内皮异质性在发育和损伤后适应中的起源和功能意义（B06）

• 批准号: 418412379
• 金额: --
• 依托单位: Forschungsgruppe Integrative Vaskuläre Biologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/418412379?language=en
• 关键词: Origin; functional; implication; coronary; endothelium

The question, whether and how the developmental ontogeny of a given cell influences its functional capacity and potential plasticity when it reaches its destination is of broad medical interest. This proposal aims to address this question in the coronary vasculature that develops as a mosaic of cells from different tissue sources and is exposed to profound physical and metabolic challenges that require adaptations in organ control throughout life. We will map the origins of coronary endothelial heterogeneity, establish their spatial and temporal distribution pattern in the maturing coronary vasculature and identify their genetic profiles as well as possible transitions in adulthood. We will determine whether and how endothelial cells of different developmental origin show divergent angiogenic capacity and plasticity in response to post-injury reactivation.

当特定细胞到达目的地时，它的发育个体发育是否以及如何影响其功能能力和潜在的可塑性，这一问题引起了广泛的医学兴趣。这项建议旨在解决冠状动脉血管系统中的这个问题，冠状动脉血管系统是由来自不同组织来源的细胞拼接而成，面临着深刻的物理和代谢挑战，需要在一生中适应器官控制。我们将绘制冠状动脉内皮细胞异质性的起源图，建立它们在成熟冠状动脉血管系统中的时空分布模式，并确定它们的遗传图谱以及成年后可能的转变。我们将确定不同发育来源的内皮细胞是否以及如何表现出不同的血管生成能力和可塑性，以响应损伤后的重新激活。