Co-stimulatory molecules as determinants of the acute immune response following cardiac ischemia reperfusion injury (B09)

共刺激分子作为心脏缺血再灌注损伤后急性免疫反应的决定因素（B09）

• 批准号: 418690303
• 金额: --
• 依托单位: Klinik für Kardiologie, Pneumologie und Angiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/418690303?language=en
• 关键词: Co; stimulatory; molecules; determinants; acute

Co-stimulatory molecules are central for shaping immune responses yet their function following myocardial infarction is not determined. Here, we will test the contribution of two co-stimulatory pathways, namely the CD40/CD40L and CD27/CD70 axes, to morphological and functional outcomes after myocardial infarction in mice. We will examine the cell type-dependent expression and function of these factors determining the immune reaction after recovery from cardiac ischemia/reperfusion injury in mice. By using genetic and pharmacological inhibition this project will help to understand the role of CD40/CD40L and CD27/CD70 following acute myocardial infarction.

共刺激分子是形成免疫反应的中心，但它们在心肌梗死后的功能尚不确定。在这里，我们将测试两个共刺激通路，即CD40/CD40L和CD27/CD70轴，对小鼠心肌梗死后的形态和功能结果的贡献。我们将研究这些决定小鼠心肌缺血/再灌注损伤恢复后免疫反应的因素的细胞类型依赖性表达和功能。通过基因和药物抑制，本项目将有助于了解CD40/CD40L和CD27/CD70在急性心肌梗死后的作用。