Association of co-stimulatory molecules with onset and recurrence of refractory uveoretinitis

各型葡萄膜炎患者CD 4 T细胞上ICOS、OX 40和4-1BB的表达均明显高于正常人。抗TNF α单抗治疗前、治疗后共刺激分子的表达均明显低于Behcet病、结节病和VKH病。用ConA刺激分离的CD 4 T细胞和CD 14细胞后，使用抑制性抗体检测在活动期和缓解期过表达的ICOS和OX 40对T细胞增殖的影响。结果显示，Th 1细胞因子和Th 17细胞因子减少。

ICOS, OX40, and 4-1BB expression on CD4 T cells in various uveitiswas signigicant higher than that in healthy individuals. And, the expressin of costimulatory molecules was signigicantly lower than that in Behcet disease, sarcoidosis, and VKH disease before and after anti-TNFα mAb treatment and systemic corticosteroid therapy, respectively. After the isolated CD4 T cells and CD14 cells were stimulated with Con A, the effects of ICOS and OX40 that were overexpressed during active and remission phases on T cell proliferation was examined using inhibitory antibodies. The results showed that Th1 cytokines and Th17 cytokines were reduced.