不眠高齢者の概日リズム異常に対する時間療法の開発及びその生理学的意義に関する研究

失眠老年人昼夜节律异常的时间疗法进展及其生理意义研究

• 批准号: 11770533
• 负责人: 三島 和夫
• 金额: $ 1.34万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Encouragement of Young Scientists (A)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11770533/
• 关键词: 光環境; 加齢; 睡眠維持障害; 概日リズム; メラトニン; 睡眠; 深部体温; 入浴; 入眠潜時; 自律神経

施設入所中の高齢者を取り巻く光環境を評価し、光環境の劣化が高齢者での血中メラトニン分泌障害及び睡眠障害の発現に果たす役割に関して検討した。対象と方法:対象は、老人保健施設に入所中の、健常老年者10名(EC群:平均年齢70.7歳)、原発性不眠を有する高齢者10名(EI群:平均年齢74.2歳)、在宅の健常若年成人10名(YC群:平均年齢20.9歳)である。研究期間は、1)光環境評価期間(14日間)、及び2)光照射期間(4週間)からなる。光照射はEI群に対してのみ、10〜12時、14〜16時までの計4時間、4週間にわたり施行した。全研究期間を通じて、睡眠パラメータ(アクチグラフ)と光センサーを用いた眼球方向での光暴露量を1分間隔で連続測定した。光環境評価期及び光照射期期最終日の翌日に、血中メラトニン分泌リズムを評価した。結果と考察:EC群及びEI群での光暴露量は、YC群に比較して有意に低下していた(p<0.01)。EI群での総光暴露量はEC群に比較して有意に低下していた(p<0.05)。光照射中には、眼球位置で平均2500lux以上の光照度が確保されていた。光照射中のEI群での総光暴露量は、YC群との間に有意差は認められなかった。メラトニン分泌リズム振幅及び夜間総分泌量ともに、3群間で有意差が認められた(YC>EC>EI、p<0.01)。4週間の光照射により、EI群の睡眠障害は有意に改善された(総睡眠時間:373.5±15.5min vs 398.8±17.1min、p<0.05;睡眠効率:69.2±2.9vs76.5±2.7%、p<0.05;中途覚醒時間:72.3±5.0vs50.2±5.1min、p<0.02)。光照射によりメラトニン分泌リズム振幅及び夜間総分泌量ともに光照射前に比較して有意に増加し(p<0.01)、YC群との間の有意差が消失した。

In the institute, people with high levels of light and poor light environment were selected to detect the damage of secretion and sleep disorders in the blood of those with poor light environment and poor light environment. Methods: there were 10 healthy elderly people (EC group: average age 70.7 years), 10 healthy adults (EI group: average age 74.2 years), 10 healthy adults (YC group: average age 20.9 years), and 10 healthy adults (average age 20.9 years). During the study period, 1) the light environment weather period (14 days), and 2) the light exposure period (4 hours). Light exposure to the EI group was performed at 10: 12 and 14: 16 for 4 hours and 4 minutes. During the whole period of the study, the light exposure in the direction of the eyeball was measured by the photoluminescence device in the direction of the eyeball. During the period of light exposure and the period of light exposure, it was the day after the day, and the blood was secreted in the first day. Results the results showed that the light exposure of EC group and EI group was lower than that of YC group (P < 0.01). The amount of light exposure in EI group was significantly lower than that in EC group. When the light hits the eye, the average position of the eyeball is above 2500lux and the illuminance is guaranteed. When the light hits the EI group, the light exposure, the YC group, the light exposure, the light exposure and the light exposure. The amplitude and volume of secretion were significantly different among the three groups (YC>EC>EI, pairltter0.01). 4. Photoperiod exposure and EI sleep disorders intentionally improve sleep disorders (sleep time: 373.5 ±15.5min vs 398.8 ±17.1min, pairltter0.05; sleep failure rate: 69.2 ±2.9 vs76.5 ±2.7%, pairltter0.05; midway wake time: 72.3 ±5.0vs50.2 ±5.1min, pairltter0.02). The amplitudes and secretions of light were measured at night. The amplitudes and secretions of light were measured before exposure to light. The results showed that there was no significant difference between the two groups (YC group).

项目成果

Mishima,K. et al.: "Supplementary administration of artificial bright light and melatonin as potent treatment for disorganized circadian rest-activity,and dysfunctional autonomic and neuroendocrine systems in institutionalized demented elderly persons."Ch

三岛，K.

Mishima K et al.: "Diminished melatonin secretion in the elderly due to insufficient environmental illumination"J Clin Endocrinol Metab. 86. 129-134 (2001)

Mishima K等人：“由于环境光照不足，老年人褪黑激素分泌减少”J Clin Endocrinol Metab。

Mishima,K. et al.: "Effects of environmental stimulation with bright light and transcranial electrostimlation on sleep and behavior disorders in elderly patients with dementia."Alzheimer's Disease and Related Disorders (K.Iqbal, D.F.Swaab, B.Winblad, H.M.

三岛，K.

Mishima, K., et al.: "Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer's type with disturbed sleep-waking"Biol. Psychiatry. 45. 417-421 (1999)

Mishima, K. 等人：“患有阿尔茨海默氏型老年痴呆症并伴有睡眠觉醒障碍的患者的褪黑激素分泌节律紊乱”Biol。