Cross-talk between redox, metabolic and hormonal retrograde chloroplast signals in the expressional regulation of nuclear encoded plastid proteins
Cross-talk between redox, metabolic and hormonal retrograde chloroplast signals in the expressional regulation of nuclear encoded plastid proteins
批准号:
42287179
负责人:
Professor Dr. Karl-Josef Dietz
金额:
$0.0万
依托单位国家:
德国
项目类别:
Research Units
财政年份:
2007
资助国家:
德国
项目状态:
已结题
起止时间:
2006-12-31 至 2014-12-31
中文摘要
基于调控动力学和相关转录因子的结果,以及第一个资助期确定的方法,第二阶段的工作计划侧重于描述代谢调节逆行信号的早期事件,特别是在轻度变化期间。(I)在荷尔蒙、氧化还原和代谢物过程中存在缺陷的野生型和定义突变体中的时间分辨转录反应将用于处理信号和代谢网络的组成部分。(Ii)逆行信号依赖于组合信号整合,例如,几种转录因子转录水平依赖于光、二氧化碳和脱落酸。因此,该项目将研究光合作用相关的氧化还原、脱落酸和代谢物信号的组合效应,以确定信号层次和整合。(Iii)已确定的AP2/EREBP家族快速反应转录调控因子和NAC转录因子的功能将在体外和体内进行研究。(Iv)转录积累和蛋白质数量之间的差异表明,转录后调控最有可能受到逆行信号的控制,这些逆行信号将使用标记有标志表位的核糖体蛋白L18拟南芥品系来比较总的和核糖体结合的mRNA。这将补充我们在转录后水平上破译氧化还原、脱落酸和代谢物信号在逆行信号中的组合效应的努力。
英文摘要
Based on the results on regulatory dynamics and involved transcription factors, and also on methods established in the first funding period, the work plan for the second period focuses on characterizing early events in retrograde signaling for metabolic adjustment, particularly during light shift. (i) Time-resolved transcriptional responses in wild type and defined mutants with defects in hormonal, redox and metabolite processes will be used to address components of the signaling and metabolic network. (ii) Retrograde signaling relies on combinatorial signal integration as seen e.g. for several transcription factor transcript level in dependence on light, CO2 and abscisic acid. Thus, the project will investigate the combinatorial effect of photosynthesis-related redox, abscisic acid and metabolite signals in order to define the signaling hierarchy and integration. (iii) The function of identified very fast responding transcriptional regulators of the AP2/EREBP family and a NAC transcription factor will be studied in vitro and in vivo. (iv) Discrepancies between transcript accumulation and protein amounts indicate posttranscriptional regulation being most likely under control of retrograde signals that will be addressed using FLAG-epitope tagged ribosomal protein L18 Arabidopsis lines to compare total and ribosome-bound mRNA. This will complement our attempt to decipher the combinatorial effect of redox, abscisic acid and metabolite cues in retrograde signaling at the posttranscriptional level.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Rapid ribonucleoprotein-dependent recruitment of mRNA to ribosomes in the high light acclimation of Arabidopsis thaliana
-
批准号:313593500
-
项目类别:Priority Programmes
-
资助金额:$0.0万
-
财政年份:2016
-
负责人:Professor Dr. Karl-Josef Dietz
-
依托单位:
The integration of the cyclophilin 20-3 and 2-cysteine peroxiredoxin thiol switches in the redox regulatory network of the chloroplast
-
批准号:251861594
-
项目类别:Priority Programmes
-
资助金额:$0.0万
-
财政年份:2014
-
负责人:Professor Dr. Karl-Josef Dietz
-
依托单位:
2-Cys Prx and PrxIIE as redox sensors, signal integrators and transmitters
-
批准号:81631128
-
项目类别:Research Grants
-
资助金额:$0.0万
-
财政年份:2008
-
负责人:Professor Dr. Karl-Josef Dietz
-
依托单位:
Redox modulation of nuclear gene expression in plants
-
批准号:5258540
-
项目类别:Research Units
-
资助金额:$0.0万
-
财政年份:2000
-
负责人:Professor Dr. Karl-Josef Dietz
-
依托单位:
Central organisation of the special research group 387 "Redox control as central regulatory mechanism in phosynthetic organisms"
-
批准号:5258610
-
项目类别:Research Units
-
资助金额:$0.0万
-
财政年份:2000
-
负责人:Professor Dr. Karl-Josef Dietz
-
依托单位:
Die Funktion pflanzlicher Peroxiredoxine in der antioxidativen Abwehr und im redox-signaling von Plastiden und Mitochondrien
-
批准号:5099652
-
项目类别:Research Grants
-
资助金额:$0.0万
-
财政年份:1998
-
负责人:Professor Dr. Karl-Josef Dietz
-
依托单位:
Regulation of synthesis and function of 12-oxophytodienoic acid in plant cell signaling
-
批准号:468843036
-
项目类别:Research Grants
-
资助金额:$0.0万
-
财政年份:--
-
负责人:Professor Dr. Karl-Josef Dietz
-
依托单位:
The dynamic function of the cytosolic redox regulatory network and the sensory role of the type II peroxiredoxins B/C/D.
-
批准号:496357082
-
项目类别:Research Grants
-
资助金额:$0.0万
-
财政年份:--
-
负责人:Professor Dr. Karl-Josef Dietz
-
依托单位:
国内基金
海外基金
登录
查看更多内容
基于NLRP3炎性小体与自噬Cross-talk探讨心康冲剂干预心肌纤维化的机制研究
-
批准号:2025JJ80174
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:邹菊英
-
依托单位:
PKM2琥珀酰化修饰介导癌细胞与血小板间Cross-talk调控胆管癌侵袭转移的研究
-
批准号:JCZRYB202500379
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:
-
依托单位:
基于破骨-成骨细胞Cross-Talk探讨内固定物存留对关节软骨退变的影响及补肾强骨治法的科学内涵
-
批准号:
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2024
-
负责人:
-
依托单位:
三痹汤激活线粒体自噬影响免疫细胞Cross talk延缓椎间盘退变的机制研究
-
批准号:
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2024
-
负责人:王楠
-
依托单位:
多环芳烃(PAHs )介导的癌细胞和Th17细胞“cross-talk”所
致免疫抑制反应在胶质瘤增殖侵袭中的作用及毒理学机制研
究
-
批准号:
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2024
-
负责人:
-
依托单位:
PGK1乙酰化修饰介导癌细胞与TAMs间Cross-talk调控胆囊癌EMT的研究
-
批准号:82373032
-
项目类别:面上项目
-
资助金额:49万元
-
批准年份:2023
-
负责人:王剑明
-
依托单位:
线粒体ClpP激动剂通过铁死亡-免疫调控cross-talk治疗急性髓细胞白血病的机制研究
-
批准号:82370171
-
项目类别:面上项目
-
资助金额:49万元
-
批准年份:2023
-
负责人:吴俣
-
依托单位:
生长激素受体通过脂肪酸介导的肝脏-脂肪Cross-talk影响脂质内稳态的研究
-
批准号:82370866
-
项目类别:面上项目
-
资助金额:49万元
-
批准年份:2023
-
负责人:吴英杰
-
依托单位:
精氨酸甲基化和泛素化修饰Cross-talk调控METTL3蛋白稳定性促进胰腺癌吉西他滨耐药的机制研究
-
批准号:82303595
-
项目类别:青年科学基金项目
-
资助金额:30万元
-
批准年份:2023
-
负责人:林承杰
-
依托单位:
Podoplanin/CD177介导供体肺泡巨噬细胞与受体中性粒细胞cross-talk参与肺移植移植物失功的机制研究
-
批准号:
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2023
-
负责人:温宗梅
-
依托单位: