Genomic position matters– integrating comparative genomics and molecular evolution
基因组位置很重要——整合比较基因组学和分子进化
基本信息
- 批准号:424626686
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Fellowships
- 财政年份:2019
- 资助国家:德国
- 起止时间:2018-12-31 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The impact of chromosomal position on the evolution of genes is not well understood, and is a crucial but missing component of comparative genomics. In this project, I will address this significant gap in knowledge by investigating the interplay of chromosomal position and molecular evolution. I will use the “model” family Brassicaceae as a study system to approach this question, as they are particularly well suited for this application due to the abundance of high quality genome sequences. All Brassicaceae share an ancient whole genome duplication event, after which their respective genome sizes were reduced. Genetic traces of this duplication are still detectable. As duplicated genes play an important role in evolution and adaptation, this offers a unique research opportunity. I will include the sister family Cleomaceae with its own independent whole genome duplication event to expand my comparative framework. This will allow me to compare the different molecular evolutionary changes that occurred after these independent genome duplications. The aim of my project is to bring together information from whole genome sequences and varying rates of molecular evolution along the chromosomes in a phylogenetic context. My project will provide important insights into evolutionary patterns underlying the dynamic genomes of plants, as well as expand the existing comparative genomics framework beyond Brassicaceae, thereby creating a valuable resource for researchers and plant breeders alike.
染色体位置对基因进化的影响尚不清楚,这是比较基因组学中一个至关重要但缺失的组成部分。在这个项目中,我将通过研究染色体位置和分子进化的相互作用来解决这一重大知识缺口。我将使用“模型”家族十字花科作为研究系统来解决这个问题,因为它们特别适合这个应用,因为它们具有丰富的高质量基因组序列。所有的芸苔科植物都有一个古老的全基因组复制事件,此后它们各自的基因组大小都减少了。这种复制的遗传痕迹仍然可以检测到。由于复制基因在进化和适应中起着重要作用,这提供了一个独特的研究机会。我将包括具有独立全基因组复制事件的姐妹科Cleomaceae,以扩展我的比较框架。这将使我能够比较在这些独立的基因组复制之后发生的不同分子进化变化。我项目的目的是在系统发育的背景下,汇集来自全基因组序列和沿着染色体的分子进化的不同速率的信息。我的项目将为植物动态基因组的进化模式提供重要的见解,并将现有的比较基因组学框架扩展到芸苔科之外,从而为研究人员和植物育种者创造宝贵的资源。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Genomic Blocks in Aethionema arabicum Support Arabideae as Next Diverging Clade in Brassicaceae
Aethionema arabicum 的基因组块支持阿拉伯科作为十字花科的下一个分化分支
- DOI:10.3389/fpls.2020.00719
- 发表时间:2020
- 期刊:
- 影响因子:5.6
- 作者:Walden;Nguyen;Mandáková;Schranz
- 通讯作者:Schranz
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Dr. Nora Hohmann其他文献
Dr. Nora Hohmann的其他文献
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