Interventions for the prevention of childhood allergies, and for promoting allergy-prevention related and COVID-19 related health literacy: living systematic reviews (Living Systematic Review)

预防儿童过敏以及促进过敏预防相关和 COVID-19 相关健康素养的干预措施：实时系统评价（Living Systematic Review）

• 批准号: 427399398
• 负责人: Professor Dr. Christian Apfelbacher, Ph.D.
• 金额: --
• 依托单位: Institut für Sozialmedizin und Gesundheitssystemforschung (ISMG)
• 依托单位国家: 德国
• 项目类别: Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/427399398?language=en
• 关键词: Interventions; prevention; childhood; allergies; promoting

Non-reproducible and conflicting health research findings entail the risk that health professionals (HPs) and the public are left confused. Evidence synthesis addresses this issue, but systematic reviews (SRs) of evidence (and consequently guidelines) go out of date quickly posing a serious risk of inaccuracy, particularly in dynamic fields such as early childhood allergy prevention (ECAP) and interventions to enhance health literacy (HL). There are presumably gaps between the best available evidence, and the practice of ECAP. Living systematic reviews (LSRs) offer an emerging chance to narrow the evidence-practice gap by keeping SRs based on evidence from randomised controlled trials continuously up to date. Traditional evidence synthesis methods, which we have applied to environmental interventions, complementary feeding (CF) and COVID-19-related HL in the general population and among HPs, provide only limited analytical possibilities. Individual Participant Data (IPD) meta-analysis (MA) has evolved as the gold standard for investigating questions beyond the average causal effect such as exploring heterogeneity or the impact of publication biases. However, a major challenge remains translating evidence in practice, which is hindered by barriers in accessing and comprehending scientific findings among HPs and parents. To enhance accessibility and usability, an evidence ecosystem is required that integrates evidence continuously and provides a user-friendly, comprehensive and reusable repository. WP2 applies the evidence synthesis paradigm to ECAP and HL. Objectives include (1) to update SRs published during the first funding phase and to expand the evidence ecosystem assisted by Epistemonikos Foundation for all routes of interventions, (2) to conduct IPD MAs for CF, pro-, pre- and synbiotica supplementation and hydrolysed formula, (3) to continue the LSR on interventions to improve COVID-19 HL, (4) to establish an LSR on ECAP-HL, (5) to involve principal target groups in creating plain language summaries through participatory research. A special focus will be on the detection of publication bias, particularly in areas with heavy industry influence. Data sharing agreements for IPD MAs will be arranged in year 1, with the analyses continuing in year 2 and concluding in year 3. The results will be disseminated through an interactive website featuring various LSRs and plain language summaries. WP2 will provide a comprehensive and living evidence ecosystem for ECAP, ECAP-HL and COVID-19-HL. It has a strong connection to WP1-Conflict of Interest which will compare our findings with the guidelines identified in the first funding phase. It is also linked to WP3-Health Professionals, WP 5-User Needs and WP7-Planetary Health, which aim to develop and pilot implement educational and system-level interventions to improve ECAP knowledge and HL.

不可复制和相互冲突的卫生研究结果带来了卫生专业人员(HPS)和公众被混淆的风险。证据综合解决了这一问题，但证据的系统评价(SRS)(以及随后的指南)很快就过时了，构成了严重的不准确风险，特别是在儿童早期过敏预防(ECAP)和提高健康素养(HL)的干预措施等动态领域。据推测，现有的最佳证据与ECAP的做法之间存在差距。活的系统评价(LSR)通过保持基于随机对照试验的证据的SRS不断更新，为缩小证据-实践差距提供了一个新兴的机会。传统的证据合成方法，我们已经应用于环境干预，普通人群中的补充喂养(CF)和新冠肺炎相关的HL，以及在HPS中，提供的分析可能性有限。个体参与者数据(IPD)荟萃分析(MA)已经发展成为调查超出平均因果效应的问题的黄金标准，例如探索异质性或发表偏见的影响。然而，一个主要的挑战仍然是在实践中翻译证据，这受到HPS和父母在获取和理解科学发现方面的障碍。为了提高可及性和可用性，需要一个证据生态系统，不断地整合证据，并提供一个用户友好、全面和可重复使用的储存库。WP2将证据合成范式应用于ECAP和HL。目标包括(1)更新在第一个供资阶段发表的SRS，并扩大Eistemonikos基金会协助的所有干预方法的证据生态系统，(2)对CF、促生素、前生物素和合生素补充剂和水解粉进行IPD评估，(3)继续开展关于改善新冠肺炎HL的干预措施的LSR，(4)建立ECAP-HL的LSR，(5)通过参与性研究让主要目标群体参与创建简明语言摘要。一个特别的重点将是检测出版偏见，特别是在具有重工业影响的领域。将在第一年安排国际方案评估的数据共享协议，第二年继续进行分析，第三年结束。结果将通过一个互动网站传播，网站上有各种LSR和通俗易懂的摘要。WP2将为ECAP、ECAP-HL和新冠肺炎-HL提供一个全面的、活的证据生态系统。它与WP1-利益冲突有很强的联系，这将把我们的调查结果与第一个筹资阶段确定的指导方针进行比较。它还与WP3--卫生专业人员、WP5--用户需求和WP7--行星健康联系在一起，旨在开发和试点实施教育和系统一级的干预措施，以改善ECAP知识和HL。