Social and Biological Mechanisms Driving the Intergenerational Impact of War on Child Mental Health: Implications for Developing Family-Based Interventions
战争对儿童心理健康产生代际影响的社会和生物机制:对制定以家庭为基础的干预措施的影响
基本信息
- 批准号:10883852
- 负责人:
- 金额:$ 6.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-10 至 2026-12-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAffectAfrica South of the SaharaAgeAnxietyAreaArticulationAutomobile DrivingAutonomic nervous systemBehavior assessmentBehavioralBiologicalBiological MarkersBiophysicsChildChild DevelopmentChild Mental HealthChild RearingChildhoodClinical assessmentsCognitionCollaborationsCollectionCommunicationCommunitiesConflict (Psychology)DataData CollectionDevelopmentEarly-life traumaEcologyEconomic DevelopmentEconomicsEducationEmotionalEmotionsEnsureEquationEthicsExposure toFamilyFamily ViolenceFemaleFundingGenerationsGovernmentGrowthHealthHeritabilityHospitalsHuman ResourcesHuman RightsIndividualInflammationInformal Social ControlInterventionInvestigationKnowledgeLengthLifeLinkLongitudinal StudiesMeasuresMental DepressionMental HealthMental disordersMigrantMilitary PersonnelModelingNational Institute of Child Health and Human DevelopmentOutcomeParent-Child RelationsParentsPathway interactionsPatternPhysiologicalPopulationPopulation HeterogeneityPreventionProcessPsyche structurePublic HealthRecording of previous eventsRefugeesResearchResearch Domain CriteriaResearch PersonnelRiskRisk FactorsSamplingScreening procedureSecuritySierra LeoneSkinSocial FunctioningSocial WorkSocial supportSoldierState GovernmentStressTechniquesTimeTraumaUnited StatesUniversitiesViolenceWarWomanYouthagedbiobehaviorbiological adaptation to stresscognitive functioncohortcopingdisplaced personemotion regulationemotional functioningimprovedinnovationintergenerationallow and middle-income countriesmalemental developmentmodifiable risknext generationoffspringparticipant retentionphysical conditioningpost-traumatic stresspreventive interventionprospectiveprotective factorssocialsocial stigmastress reactivitystressorsubstance usesupport toolstelomeretraittransmission processtrauma exposureyoung adult
项目摘要
PROJECT SUMMARY
Violence and humanitarian crises are common in the lives of children around the world, particularly in low- and
middle-income countries. Exposure to war-related violence is detrimental to the mental health of parents and
children, but research exploring mechanisms by which emotional and behavioral disruptions are transmitted to
subsequent generations remains nascent, especially in Sub-Saharan Africa. To help address this gap, a study
of war-affected youth has been underway since 2002 following a cohort of war-affected children—many, both
male and female, former child soldiers—in Sierra Leone into young adulthood, and now parenthood. A prior
NICHD-funded R01 (R01HD073349) demonstrated how childhood war-related trauma and loss contributed to
mental health problems in adulthood. In 2017, a cross-sectional sample of intimate partners and biological
offspring was added to the sample to examine linkages between early trauma exposure and both intimate
partner and parent-child relationships. Knowledge to date of how war-related stressors “get under the skin,” to
become heritable biophysical traits and the implications for the mental health of the next generation remain
limited. Of relevance are the Research Domain Criteria-related constructs of self-regulation and stress
reactivity and how they influence emotional, cognitive and social functioning of children. The proposed
research comprises a significant advance in the 20-year history of this study by advancing understanding of
potential biological embedding of stress responses intergenerationally. Building on four prior waves of data
collection, biological measures of stress reactivity and self-regulation (autonomic nervous system reactivity,
inflammation, telomere length) will be collected in a sample of parents exposed to significant trauma in
childhood and extended also to intimate partners and offspring. Strong capacity-building collaborations with
Sierra Leone’s University of Makeni (UNIMAK) and Kenema Government Hospital (KGH) will support the
ethical collection of new stress biomarker data and clinical assessments of parent-child synchrony, health, and
anthropometric data in biological offspring aged 7–24. Key study innovations are (a) rare prospective data on
parental trauma exposure and longitudinal information on risk and protective factors operating across the
social ecology; (b) data on biological embedding of stress responses related to parental trauma; and (c) the
opportunity to examine both mental health and physiological outcomes in biological offspring in war-affected
families over time. Advanced statistical techniques (e.g., latent class growth models, structural equation
models, lagged effects models) will articulate mechanistic pathways and priority targets for intervention.
Collaborations between investigators, UNIMAK, KGH, as well as community advisory boards will inform study
implementation, ensure strong retention of participants, and provide channels for dissemination. Analyses will
inform screening tools to identify families for preventive interventions. Intervention targets identified have
implications not just for war-affected settings, but also for assisting diverse populations affected by violence
and trauma, including migrants and refugees.
项目概要
暴力和人道主义危机在世界各地儿童的生活中很常见,特别是在低收入和低收入国家。
中等收入国家。接触与战争有关的暴力不利于父母和孩子的心理健康
儿童,但研究探索情绪和行为障碍传递给儿童的机制
后代仍处于新生阶段,特别是在撒哈拉以南非洲地区。为了帮助解决这一差距,一项研究
自 2002 年以来,针对一群受战争影响的儿童(其中许多人都
男性和女性,前儿童兵——在塞拉利昂进入青年期,现在为人父母。先前的
NICHD 资助的 R01 (R01HD073349) 展示了儿童战争相关创伤和损失如何导致
成年后的心理健康问题。 2017 年,亲密伴侣和生物的横断面样本
后代被添加到样本中,以检查早期创伤暴露与亲密关系之间的联系
伴侣和亲子关系。迄今为止关于战争相关压力因素如何“深入人心”的知识
成为可遗传的生物物理特征,对下一代心理健康的影响仍然存在
有限的。相关的是与研究领域标准相关的自我调节和压力结构
反应性以及它们如何影响儿童的情绪、认知和社会功能。拟议的
这项研究在 20 年的历史中取得了重大进展,通过增进对
代际应激反应的潜在生物嵌入。以之前四波数据为基础
收集、应激反应性和自我调节的生物测量(自主神经系统反应性、
炎症、端粒长度)将收集在遭受重大创伤的父母样本中
童年,也延伸到亲密伴侣和后代。与以下机构开展强有力的能力建设合作
塞拉利昂马克尼大学 (UNIMAK) 和凯内马政府医院 (KGH) 将支持
新压力生物标志物数据的伦理收集以及亲子同步性、健康和健康的临床评估
7-24 岁生物后代的人体测量数据。关键的研究创新是 (a) 罕见的前瞻性数据
父母的创伤暴露以及整个过程中风险和保护因素的纵向信息
社会生态学; (b) 与父母创伤相关的应激反应的生物嵌入数据; (c)
有机会检查受战争影响的生物后代的心理健康和生理结果
随着时间的推移,家庭。先进的统计技术(例如,潜在类别增长模型、结构方程
模型、滞后效应模型)将阐明干预的机制途径和优先目标。
研究人员、UNIMAK、KGH 以及社区咨询委员会之间的合作将为研究提供信息
落实,确保参与者的强大保留,并提供传播渠道。分析将
告知筛查工具以确定家庭进行预防性干预。确定的干预目标有
不仅对受战争影响的环境产生影响,而且对援助受暴力影响的不同人群也产生影响
和创伤,包括移民和难民。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Theresa Stichick Betancourt其他文献
Theresa Stichick Betancourt的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Theresa Stichick Betancourt', 18)}}的其他基金
Social and Biological Mechanisms Driving the Intergenerational Impact of War on Child Mental Health: Implications for Developing Family-Based Interventions
战争对儿童心理健康产生代际影响的社会和生物机制:对制定以家庭为基础的干预措施的影响
- 批准号:
10375033 - 财政年份:2022
- 资助金额:
$ 6.39万 - 项目类别:
ACHIEVE Administrative Supplement for Trainee Funding (OBSSR)
ACHIEVE 实习生资助行政补充 (OBSSR)
- 批准号:
10853843 - 财政年份:2022
- 资助金额:
$ 6.39万 - 项目类别:
ACHIEVE Administrative Supplement for Trainee Funding (NCI)
ACHIEVE 实习生资助行政补充 (NCI)
- 批准号:
10853953 - 财政年份:2022
- 资助金额:
$ 6.39万 - 项目类别:
Addressing the Research Capacity Gap in Global Child and Adolescent Health Disparities Utilizing Implementation and Data Sciences among Vulnerable Populations in Resource-limited Settings (ACHIEVE)
利用资源有限环境中弱势群体的实施和数据科学来解决全球儿童和青少年健康差异的研究能力差距(ACHIEVE)
- 批准号:
10627050 - 财政年份:2022
- 资助金额:
$ 6.39万 - 项目类别:
Addressing the Research Capacity Gap in Global Child and Adolescent Health Disparities Utilizing Implementation and Data Sciences among Vulnerable Populations in Resource-limited Settings (ACHIEVE)
利用资源有限环境中弱势群体的实施和数据科学来解决全球儿童和青少年健康差异的研究能力差距(ACHIEVE)
- 批准号:
10644158 - 财政年份:2022
- 资助金额:
$ 6.39万 - 项目类别:
ACHIEVE Administrative Supplement for Trainee Funding (ODSS)
ACHIEVE 实习生资助行政补充 (ODSS)
- 批准号:
10853886 - 财政年份:2022
- 资助金额:
$ 6.39万 - 项目类别:
Addressing the Research Capacity Gap in Global Child and Adolescent Health Disparities Utilizing Implementation and Data Sciences among Vulnerable Populations in Resource-limited Settings (ACHIEVE)
利用资源有限环境中弱势群体的实施和数据科学来解决全球儿童和青少年健康差异的研究能力差距(ACHIEVE)
- 批准号:
10590630 - 财政年份:2022
- 资助金额:
$ 6.39万 - 项目类别:
Addressing the Research Capacity Gap in Global Child and Adolescent Health Disparities Utilizing Implementation and Data Sciences among Vulnerable Populations in Resource-limited Settings (ACHIEVE)
利用资源有限环境中弱势群体的实施和数据科学来解决全球儿童和青少年健康差异的研究能力差距(ACHIEVE)
- 批准号:
10473075 - 财政年份:2022
- 资助金额:
$ 6.39万 - 项目类别:
ACHIEVE Administrative Supplement for Trainee Funding (ODP)
ACHIEVE 实习生资助行政补充 (ODP)
- 批准号:
10853920 - 财政年份:2022
- 资助金额:
$ 6.39万 - 项目类别:
Expanding the Reach of Evidence-Based Mental Health Treatment: Diffusion and Spillover of Mental Health Benefits Among Peer Networks and Caregivers of Youth Facing Compounded Adversity in Sierra Leone
扩大循证心理健康治疗的范围:在塞拉利昂面临复杂逆境的青少年的同伴网络和照顾者中传播和溢出心理健康益处
- 批准号:
10375098 - 财政年份:2019
- 资助金额:
$ 6.39万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 6.39万 - 项目类别:
Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 6.39万 - 项目类别:
Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 6.39万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 6.39万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 6.39万 - 项目类别:
Standard Grant
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 6.39万 - 项目类别:
Discovery Early Career Researcher Award
RUI: Evaluation of Neurotrophic-Like properties of Spaetzle-Toll Signaling in the Developing and Adult Cricket CNS
RUI:评估发育中和成年蟋蟀中枢神经系统中 Spaetzle-Toll 信号传导的神经营养样特性
- 批准号:
2230829 - 财政年份:2023
- 资助金额:
$ 6.39万 - 项目类别:
Standard Grant
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 6.39万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 6.39万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 6.39万 - 项目类别:
Grant-in-Aid for Scientific Research (C)














{{item.name}}会员




