Quantitative magnetorelaxometry for magnetic nanoparticle monitoring for assisting human cancer therapies (quantMRX)

用于辅助人类癌症治疗的磁性纳米粒子监测的定量磁松弛测量法 (quantMRX)

• 批准号: 428329263
• 负责人: Dr. Frank Wiekhorst
• 金额: --
• 依托单位: UMIT TIROL - Private Universität für Gesundheitswissenschaften und -technologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/428329263?language=en
• 关键词: Quantitative; magnetorelaxometry; magnetic; nanoparticle; monitoring

The goal of this project is to develop and provide an imaging modality for the quantitative detection of magnetic nanoparticles (MNP) for the diagnostic support of MNP-based cancer therapies. In these novel treatment approaches, MNP is used to transport medically active substances to the tumor in a targeted way (Magnetic Drug Targeting) or to generate heat for fighting cancer cells in a locally restricted way by means of MNP (magnetic hyperthermia). Thereby, the quantitative imaging detection of the MNP distribution in the human body is essential for the assessment and the individual control of the therapy progress. The method of magnetic relaxometry (MRX) provides a mature measurement technology which has already demonstrated its fundamental suitability for the sensitive and specific detection of MNP in tissue in pre-clinical applications. In this project, the required technology is to be further developed on this basis so that MNP distributions in specific human body regions such as the brain, the prostate, the lymphatic nodes, the gastrointestinal tract, the lungs or the extremities can be quantitatively imaged.Particular attention is given thereby to the establishment of procedures for the prompt demonstration of MNP distributions immediately during, or after the MRX measurements (online monitoring). For this purpose, novel approaches for data processing and for the reconstruction of the distributions with high spatial resolution and, at the same time, with a substantial reduction of the computing time, are to be realized. In addition, approaches for the multi-modal integration of the quantitative MNP distribution and the associated anatomic structure of the body region are to be developed, with the anatomic data being obtained by established procedures such as CT, MRT or laser scanning of the body surface.Another field of activity in this project consists in the investigation of the possibilities of MRX imaging for the demonstration of molecular changes in the body. The MRX signals contain information on the local viscosity in the immediate vicinity of the MNPs. This information can also be imaged and used for the investigation of physiological processes in the body. In the present project, special body-part phantoms, which image the physiological and physical parameters in selected therapy scenarios and which can be loaded in a defined way with MNPs, are to be developed for the evaluation of MRX imaging. These investigations are carried out in close cooperation with our clinical partners to ensure the medical relevance and to take the clinical requirements and the demands on the imaging modality into account from a medical point of view.When the project objectives are achieved, all technical requirements shall be complied with in order to apply MRX imaging of MNPs to new MNP-based cancer therapies in humans.

本项目的目标是开发和提供一种定量检测磁性纳米颗粒(MNP)的成像模式，为基于MNP的癌症治疗提供诊断支持。在这些新的治疗方法中，MNP被用来以靶向的方式(磁性药物靶向)将医学活性物质输送到肿瘤中，或者通过MNP(磁热疗)以局部受限的方式产生热量以对抗癌细胞。因此，对人体内MNP分布的定量成像检测对于评估和个体化控制治疗进程是必不可少的。磁弛豫法(MRX)提供了一种成熟的测量技术，已经证明了其在临床前应用中对组织中MNP的灵敏和特异性检测的基本适用性。在这个项目中，将在此基础上进一步开发所需的技术，以便能够定量地显示MNP在人体特定区域的分布，如大脑、前列腺、淋巴结节、胃肠道、肺或四肢，从而特别注意建立程序，以便在MRX测量期间或之后立即显示MNP分布(在线监测)。为此目的，将实现数据处理和重建高空间分辨率分布的新方法，同时大幅减少计算时间。此外，还将开发将人体区域的定量MNP分布和相关的解剖结构进行多模式整合的方法，并通过已有的程序获得解剖数据，如CT、MRT或激光扫描人体表面。该项目的另一个活动领域是研究MRX成像显示人体分子变化的可能性。MRX信号包含关于MNPs附近的局部粘度的信息。这些信息也可以被成像并用于研究身体的生理过程。在本项目中，将开发特殊的身体部位体模，它可以成像选定的治疗方案中的生理和物理参数，并可以通过定义的方式与MNPs一起加载，用于评估MRX成像。这些研究是与我们的临床合作伙伴密切合作进行的，以确保医学相关性，并从医学角度考虑临床要求和对成像方式的要求。当项目目标实现时，应遵守所有技术要求，以便将MNPs的MRX成像应用于基于MNP的人类癌症新疗法。