Establishing thermal noise magnetometry for magnetic nanoparticle characterization

磁性纳米颗粒由于其在生物医学和纳米技术中的广泛应用，目前是一个主要的研究领域。为了充分发挥这些应用的潜力，有必要对纳米颗粒及其物理行为有一个全面的了解。所有传统的磁强计方法都是通过测量磁性纳米颗粒对外部施加的激励场的响应来获得这些信息的。这是不利的，因为已知这些激发会影响聚集状态，从而影响测量结果。与以往的任何一种方法不同，热噪声磁强计（TNM）是一种不依赖于任何外部激励场的平衡测量方法。因此，在接近人体组织的环境中，TNM能够在没有外场的情况下测量颗粒特性，在那里它们可以应用于读出结合测定和估计生物聚集量。该项目建议书的作者最近证明了TNM的主要可行性。在这个项目中，我们希望通过展示其补充传统磁性表征技术的潜力及其在应用中的实用性来建立这种新的测量方法。最后，我们的目标是开发一个不太复杂的设置，以增加其可访问性。

Magnetic nanoparticles are currently a major area of research due to their numerous applications in biomedicine and nanotechnology. For these applications to reach their full potential, it is essential to have a thorough knowledge about the nanoparticles and their physical behaviour. All conventional magnetometry methods gain this information by measuring the response of the magnetic nanoparticles to an externally applied excitation field. This is disadvantageous because these excitations are known to influence the aggregation state and thus the measurement results. Unlike any of the previous methods, Thermal Noise Magnetometry (TNM) is an equilibrium measurement method that does not rely on any external excitation field. Therefore, TNM is able to measure the particle properties without an external field in an environment close to the tissue in the human body, where they might be applied to read out binding assays and estimate the amount of biological aggregation.The principal feasibility of TNM was recently demonstrated by the authors of this project proposal. In this project, we want to establish this new measurement method by demonstrating its potential to complement conventional magnetic characterization techniques and its usefulness in applications. Finally, we aim to develop a less complex setup to increase its accessibility.