Heparan sulfate proteoglycan from smooth muscle cell basal lamina: It's role in cell signalling.

来自平滑肌细胞基底层的硫酸乙酰肝素蛋白多糖：它在细胞信号传导中的作用。

• 批准号: LX0667295
• 负责人: Em/Prof John Whitelock
• 金额: $ 1.1万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Linkage - International
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LX0667295
• 关键词: Heparan; sulfate; proteoglycan; smooth; muscle

Heart disease is the major killer of people in the Western world. central to this disease is the killing of heart muscle tissue to it being starved of oxygen via a "heart attack". One of the common treatments is coronary artery bypass surgery, however, the supply of vessels that can be used is limited. In order to provide an alternative supply of vessels, we are aiming to engineer blood vessels in the laboratory. The major cell of the wall of arteries, the smooth muscle cell, is critical to normal functioning and integration of these transplanted arteries. To do this we will need to understand the cell signalling responses of these cells in relation to molecules in their surrounding environment.

心脏病是西方世界人民的主要杀手。 这种疾病的核心是通过“心脏病发作”杀死心肌组织，使其缺氧。 冠状动脉搭桥手术是常见的治疗方法之一，然而，可以使用的血管供应是有限的。 为了提供血管的替代供应，我们的目标是在实验室中设计血管。 动脉壁的主要细胞，平滑肌细胞，对这些移植动脉的正常功能和整合至关重要。 要做到这一点，我们需要了解这些细胞与周围环境中分子的细胞信号反应。