Biomimetic blood bag materials for prolonged platelet storage

用于延长血小板储存的仿生血袋材料

• 批准号: LP140101056
• 负责人: Em/Prof John Whitelock
• 金额: $ 25.38万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-03-01 至 2021-02-28
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP140101056
• 关键词: Biomimetic; blood; bag; materials; prolonged

Platelet storage is limited to five to seven days before there is a reduction in viable platelets. This results in a continual mismatch between supply and demand resulting in patients in remotes areas or those that have rare phenotypes missing out on platelets. It also results in the wastage of platelets because they expire before they can be used clinically. This project aims to extend the platelet shelf life beyond seven days by developing biomimetic blood bag materials that reflect the natural molecular structures of blood vessels through the use of novel synthetic and biological materials. With the realisation of longer platelet storage times, this project aims to have significant impacts on the health and economic benefits of Australians.

在活血小板减少之前，血小板储存被限制在5 - 7天。这导致供应和需求之间的持续不匹配，导致偏远地区的患者或那些具有罕见表型的患者错过了血小板。它还会导致血小板的浪费，因为它们在临床使用之前就已经过期了。本项目旨在通过使用新型合成材料和生物材料，开发反映血管天然分子结构的仿生血袋材料，将血小板的保质期延长至7天以上。随着血小板储存时间的延长，该项目旨在对澳大利亚人的健康和经济效益产生重大影响。