Identification and characterisation of genes required for cardiac morphogenesis

心脏形态发生所需基因的鉴定和表征

• 批准号: nhmrc : 1002884
• 负责人: Dr Kelly Smith
• 金额: $ 28.99万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-characterisation-genes-cardiac-morphogenesis/108869
• 关键词: Identification; characterisation; genes; required; cardiac

The heart is the first organ to become functional as an embryo forms, reflecting its critical role in sustaining life. Mistakes that occur as the heart develops have devastating consequences for an individualÍs survival and health. We have identified two zebrafish mutants with heart defects and, using sophisticated imaging and genetic studies, will investigate these defects and identify the genes responsible. This research will improve our understanding of correct and diseased heart formation.

心脏是作为胚胎形成的第一个具有功能的器官，反映了它在维持生命方面的关键作用。心脏发育过程中出现的错误会对S的生存和健康造成毁灭性的后果。我们已经确定了两个患有心脏缺陷的斑马鱼突变体，并将利用复杂的成像和遗传学研究，调查这些缺陷并确定相关基因。这项研究将提高我们对正确和病态心脏形成的理解。