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Endogenous Appetite Modifiers of the Domestic Animals.

家畜的内源性食欲调节剂。

基本信息

批准号：
01480096
负责人：
MAKIMURA Susumu
金额：
$ 4.42万
依托单位：
Miyazaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1990
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01480096/
关键词：
Appetite Food Intake Body Temperature 2B40 245TP Ruminants Chickens Domestic Animals ZB40 Food intake 2-buten-4-olide Feeding behavior chickens ruminants Hypothalamus

项目摘要

In order to apply newly-characterized endogenous appetite modifiers to the domestic animals, their existences and variation in the blood of animals, the effects of their administration on food intake, behavior and some physiological functions, and their mechanisms were investigated.The existence of 2B40 (2-buten-4-olide) in animals was confirmed by the gaschromatogram of their plsma. The concentration was the highest in sheep, nextly in cattle, and also higher in pig than in chickens and rats. It was increased after feeding and decreased after fasting, during which the lowered level was kept for 120 hrs in ruminants.Peripheral administration of 2B40 in sheep suppressed eating and also rumination. 2B40 administration in chickens suppressed eating dose-dependently, even if orally, and it also induced hypothermia and suppressed the gastric movement.Hypothermia by 2B40 was due to trancient acceleration of heat loss and chronic inhibition of heat production, which was confirmed using a calo … More rimeter. This phenomenon was shown to be attributed to let-down of the set-point for controlling body temperature. Microinjection of 2B40 into the hypothalamic heat loss center induced a slight hyperthermia, and the injection into the heat production center induced severe hypothermia. On the other hand, the central neurochemical mechanism of this hypothermia was surveyed using the blockers to H1, H2 and 5HT receptors. Results were not obtained to in dicate that the hypothermia was induced via these receptor mechanisms.When 245TP (2, 4, 5-trihydroxy pentanoic acid gamma-lactone) of the same dose to rats was given to chickens peripherally, no clear acceleration of food intake was seen. But microinjection of 245TP into the lateral hypothalamic area accelerated appetite and their food intake was twiced. the existence of this substance was confirmed by the gaschromatogram of chicken's plasma.In conclusion, 2B40 and 245TP were confirmed to be endogenous appetite modifiers in the domestic animals. Less

为了将新发现的内源性食欲调节剂应用于家畜，本文研究了内源性食欲调节剂2B 40在动物血液中的存在与变化，给药后对动物摄食、行为和某些生理功能的影响及其作用机制，并通过血浆色谱图证实了2B 40（2-丁烯-4-基）在动物体内的存在。绵羊体内的浓度最高，牛次之，猪体内的浓度也高于鸡和大鼠。2B 40在反刍动物中可持续120小时，在此期间，2B 40可抑制绵羊的摄食和反刍。2B 40对鸡的摄食抑制呈剂量依赖性，即使是口服，也可诱导体温降低并抑制胃运动。2B 40引起的体温降低是由于短暂加速热损失和长期抑制产热，这一点已通过使用热平衡仪证实。 ...更多信息长度计这种现象被证明是由于控制体温的设定点下降。下丘脑失热中枢微量注射2B 40引起轻度体温升高，产热中枢微量注射2B 40引起重度体温降低。另一方面，用H_1、H_2和5-HT受体阻断剂探讨了这种低温的中枢神经化学机制。当245 TP（2，4，5-trihydroxypentanoic acid gamma-lactone，245 TP）以与大鼠相同的剂量经外周给予鸡时，未见明显的摄食加速。但下丘脑外侧区微量注射245 TP可促进食欲，使摄食量增加一倍。2B 40和245 TP是家畜内源性食欲调节剂。少