Synergy between defence mechanisms and antimicrobial chemotherapy in urinary tract infections

尿路感染防御机制与抗菌化疗的协同作用

• 批准号: 01480384
• 负责人: MACHIDA Toyohei
• 金额: $ 3.71万
• 依托单位: Jikei University, School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01480384/
• 关键词: Urinary Tract Infections; Defence Mechanisms; Antimicrobial Chemotherapy; Synasism

We investigated the synergy between defence mechanisms and antimicrobial chemotherapy in urinary tract infections in order to determine therapeutic fegimen for utinary tract infections in immunocompromised host.1. Bactericidal Activities of Neutrophil in Human Urine :Most leukocytes, which appear in urine from tlie patients with urinary tract infections, are neutrophils. And these neutrophits have bactericidat activities at maximum in hypotonic urine. 'Fliefefore, adequate hydration is advantageous at the treatment for urinary tract infections.2. Influence of Antimicrobial Agents on Bactericidat Activities of Leukocytes :New quinotones and penems enhance the bactericidal activities of nelitrophils and monocytes at certain concentrations. however, new quinolones suppress the bactericidal activities of neutropiiils and monocutes at high concentration. Therefore, new quinolones and penems should be administered against the urinary tract infections in imniunocompromised host.3. Relationship between Bactericidal Activities of Leuukocytes and Seriousness of Urinary Tract Infections in Immunocompromised Itats :We made the pseudomonel pyelonephritis model of neutropenic rats, which were pretreated with cyclophosphaniide. And the retationship between the bactericidal activities of leukocytes arid the seriousness of pyelonephritis in neutropenic rats was seen. Furthermore, granurocyte colony-stimulating factor (C-CSF) prevented the seriousness of psetidomonal pyf, , Ioriephritis in neutropenic rats.4. Prevention and 1'featm (, , nt for llyelonepl) ritis in Immunocompromised Host :The measurement of the bactericidal activity (, , s of I (., tikocytes is important to foresee the seriousn -ss of pyelorit. -phritis in immunocompromised host. And G-CSF prevents the seriousness of pyclonephritis. New qtjinotones or penems should be administered against pyelonephritis in such patients for enpancement of the bactericidal activities of leukocytes.

我们研究了尿路感染中防御机制和抗菌药物化疗之间的协同作用，以确定免疫功能低下宿主中尿路感染的治疗方案。人尿中中性粒细胞的杀菌活性：尿路感染患者尿中出现的大多数白细胞是中性粒细胞。这些中性粒细胞在低渗尿中具有最大的杀菌活性。因此，充分的水合作用有利于治疗尿路感染。抗菌药物对白细胞杀菌活性的影响：新喹诺酮类和青霉烯类在一定浓度下可增强嗜中性粒细胞和单核细胞的杀菌活性。然而，新的喹诺酮类在高浓度下抑制抗真菌药和单杀真菌药的杀菌活性。因此，免疫功能低下患者的泌尿系感染需要新的喹诺酮类和青霉烯类药物的治疗.白细胞杀菌活性与免疫功能低下者尿路感染严重程度的关系：我们用环磷酰胺预处理，建立了大鼠假单胞菌性肾盂肾炎模型。白细胞的杀菌活性与肾盂肾炎的严重程度有关。此外，粒细胞集落刺激因子（C-CSF）可预防假性脓毒症的严重性.免疫功能低下的宿主对伊洛奈普的预防和杀菌活性的测定tikocytes是预测肾盂肾炎严重程度的重要指标。- 免疫受损宿主的肾炎。G-CSF可预防肾盂肾炎的严重性。对这类患者应给予新的喹诺酮类或青霉烯类药物，以增强白细胞的杀菌活性。

项目成果

H. Mitani, H. Kiyota, T. Machida, et. al.: "Influence of new Quinolones on Bactericidal Activities of Leukocytes" Jpn. J. Urol.82. 321 (1991)

H. Mitani、H. Kiyota、T. Machida 等。

三谷 比呂志,清田 浩: "白血球殺菌能におよぼすニュ-キノロン剤の影響" 感染症学会雑誌. 66. 59-65 (1992)

Hiroshi Mitani、Hiroshi Kiyota：“新型喹诺酮类药物对白细胞杀菌活性的影响”日本传染病学会杂志 66. 59-65 (1992)。

H. Kiyota, T. Machida, S. Onodera, et. al.: "Influence of Imipenem on Bactericidal Activities of Leukocytes" Jpn. J. Urol.82. 321 (1991)

H. Kiyota、T. Machida、S. Onodera 等。

清田 浩,町田 豊平: "白血球殺菌能に及ぼすイミペネムの影響" 日泌尿会誌. 82. 321- (1991)

Hiroshi Kiyota、Toyohira Machida：“亚胺培南对白细胞杀菌能力的影响”泌尿学会杂志 82. 321- (1991)。

三谷 比呂志: "ニュ-キノロン剤の好中球殺菌能に及ぼす影響" 日本泌尿器科学会雑誌. 82. 321 (1991)

Hiroshi Mitani：“新喹诺酮类药物对中性粒细胞杀菌活性的影响”日本泌尿外科协会杂志 82. 321 (1991)。