Role of somatomedin C in anabolism and catabolism of body proteins

生长调节素 C 在体内蛋白质合成代谢和分解代谢中的作用

• 批准号: 02453123
• 负责人: NOGUCHI Tadashi
• 金额: $ 4.03万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02453123/
• 关键词: Somatomedin C; Insulin-like growth factor-I; Protein nutrition; IGF-binding proteins; Insulin; Growth; IGF-I; IGF-I mRNA; インスリン様成長因子1; インスリン様成長因子結合タンパク質; IGF-1; インスリン様成長因子I; IGFーI; 実験的糖尿病; 実験的肝障害; 体タンパク質同化; インスリン様成長因子I結合タンパク質; 食品タンパク質; 体

Somatomedin C, or insulin-like growth factor-I (IGF-I), is a peptide hormone which has been suggested to play an important role in growth and protein metabolism in animals. The present investigations were planned to elucidate the physiological significance of IGF-I in protein anabolism and catabolism in rats.(1) Plasma concentration of IGF-I increased under good nutritional conditions and decreased under poor nutritional conditions.(2) Plasma IGF-I conjugated with insulin-like growth factor binding protein (IGFBP)-3 increased under good nutritional conditions. In concomitant with this increase in IGF-I-IGFBP-3 complex, the plasma concentration of IGFBP-3 increased significantly. On the contrary, plasma concentrations of IGFBP-1 and IGFBP-2 decreased extensively under good nutritional conditions.The mechanisms of these changes in plasma concentrations of IGF-I and IGFBPs were investigated by determining mRNA contents of these proteins in liver or by measuring the rate of mRNA synthesis in liver. The results gave new perspectives concerning the role of IGF-I and IGFBPs in protein anabolism and catabolism in animals.

生长调节素C，或胰岛素样生长因子-I（IGF-I），是一种肽类激素，已被认为在动物的生长和蛋白质代谢中起重要作用。本研究旨在阐明IGF-I在大鼠蛋白质摄取和代谢中的生理意义。(1)胰岛素样生长因子-I的血浆浓度在良好的营养条件下增加，在营养不良的条件下下降。(2)在良好的营养条件下，胰岛素样生长因子结合蛋白（IGFBP）-3结合的血浆IGF-I增加。伴随着IGF-I-IGFBP-3复合物的增加，IGFBP-3的血浆浓度显著增加。通过测定肝脏中IGF-I和IGFBPs的mRNA含量或mRNA合成速率，研究了IGF-I和IGFBPs血浆浓度变化的机制。这些结果为IGF-I和IGFBPs在动物体内蛋白质代谢中的作用提供了新的视角。

项目成果

Noguchi,T.Umezawa,T.et al.: "Effect of protein deprivation on insulin-like growth factor-binding proteins in rats." British Journal of Nutrition. 66. 105-116 (1991)

Noguchi,T.Umezawa,T.et al.：“蛋白质剥夺对大鼠胰岛素样生长因子结合蛋白的影响。”

Noguchi,T. Miura,Y.et al.: "Effect of dietary proteins on insulin-like growth factor-1.(IGF-1)messenger ribonucleic acid content in rat liver." British Journal of Nutrition. 67. 257-265 (1992)

野口，T.

Noguchi,T.Miura,Y.et al.: "Effects of dexamethasone on the production of insulin-like growth factor-I and insulin-like growth factor binding proteins in primary cultures of rat hepatocytes." Bioscience,Biotechnology and Biochemistry. 56. 1396-1400 (1992)

Noguchi,T.Miura,Y.等人：“地塞米松对大鼠肝细胞原代培养物中胰岛素样生长因子-I 和胰岛素样生长因子结合蛋白产生的影响。”

Miura, Y., Kato, H. and Noguchi, T.: "Effect of dietary protein on insulin-like growth factor-I (IGF-I) messenger ribonucleic acid content in rat liver." British Journal of Nutrition. Vol.67. 257-265 (1992)

Miura, Y.、Kato, H. 和 Noguchi, T.：“膳食蛋白质对大鼠肝脏中胰岛素样生长因子-I (IGF-I) 信使核糖核酸含量的影响。”

T.Umezawa,Y.Ohkoshi,Y.Miura,H.Kato,T.Noguchi: "Effect of protein deprivation on insulinーlike growth factor binding proteins in rats." British Journal of Nutrition. 65. (1991)

T. Umezawa、Y. Ohkoshi、Y. Miura、H. Kato、T. Noguchi：“蛋白质剥夺对大鼠胰岛素样生长因子结合蛋白的影响”65。（1991 年）