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Analysis on the role of circulating blood volume on body temperature regulation and exercise performance.

循环血量对体温调节和运动表现的作用分析

基本信息

批准号：
02454130
负责人：
MORIMOTO T.
金额：
$ 3.65万
依托单位：
Kyoto Prefectural University of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

项目摘要

The aim of this project was to test a working hypothesis that blood volume has an important role in the regulations of body temperature and exercise performance. To test the hypothesis, we conducted a series of experiments on human subjects and rats, and attempts were made to elucidate the role of central venous pressure as the input signal for the changes in blood volume and the regulatory responses to maintain blood volume were analyzed.In human experiments, we established a method to determine right atrial pressure under exercising condition, and the values were compared with blood levels of lactate, Na, catecholamine, ADH and ANP, and analyzed their roles to regulate blood volume. We also succeeded to measure blood volume of exercisingrat, and found a decrease in blood volume and an increase in plasma K concentration during exercise, proportional to exercise intensity.Rats exposed to thermal stress showed increase in total peripheral vascular resistance proportional to the lowering of central venous pressure. When vagus nerve was cut, this response was reduced by about 40%, which indicates that the lowering of central venous pressure is prevented by lowering peripheral vascular resistance. We also found that the electrical stimulation of the central end of served vague induced the increase in vascular resistance, and the vascular compliance of hindquarter of rat is about 1/10 of total vascular compliance. All these together suggest to work to maintain central venous pressure under heat stress and during exercise.

该项目的目的是检验一个工作假设，即血容量在体温和运动表现的调节中起着重要作用。为了验证这一假设，我们在人体和大鼠上进行了一系列实验，试图阐明中心静脉压作为血容量变化的输入信号的作用，并分析了维持血容量的调节反应;在人体实验中，我们建立了运动条件下右心房压的测定方法，并将其值与血乳酸水平进行了比较，结果：①血浆中Na+、儿茶酚胺、ADH、ANP的含量均明显高于正常对照组，并分析了它们对血容量的调节作用。我们还成功地测量了运动大鼠的血容量，发现运动时血容量减少，血浆K浓度增加，与运动强度成正比，热应激大鼠外周血管总阻力增加，与中心静脉压降低成正比。当切断迷走神经时，这种反应降低了约40%，这表明通过降低外周血管阻力来防止中心静脉压的降低。电刺激尾椎中央端可引起血管阻力增加，尾椎血管顺应性约为总血管顺应性的1/10。所有这些都表明，在热应激和运动期间，应努力维持中心静脉压。