Integrative analysis of physiological adaption to environmental stress.

这次合作研究的目的是从不同的角度分析生物对环境胁迫的适应机制，并获得生理适应的综合观点。作为调节反应，从体温调节、循环调节、体液调节、代谢调节等方面研究了从单个细胞到全身和行为的适应机制。包括外周总阻力与中心静脉压的关系，局部加热时皮肤血流的调节，皮肤血流与交感神经活动的关系，发热与交感神经活动的局部反应，神经节苷脂对棕色脂肪组织产热的影响，多肽和细胞因子对体液和循环功能调节的影响，内毒素、IL-1和热应激对巨噬细胞活性的影响，中枢神经系统中儿茶酚胺对昼夜节律的影响，边缘系统对空间识别的作用，在研究期间召开了两次科学会议，在介绍这些研究工作的基础上，就这些对环境应激的适应性反应的综合观点、这些反应的相互作用、适应功能的层次结构以及这些适应性变化的控制机制进行了热烈的讨论，这些讨论对小组每个成员都是非常有启发的，并将通过他们发表的作品对他们的工作和环境生理学家产生反馈作用。

The aim of this Cooperative research was to analyze the adaptive mechanism of living organism to environmental stresses from different aspects, and to obtain the integrative view of physiological adaptation. As the regulatory responses, the adaptive mechanisms were studied from body temperature regulation, circulatory adjustments, body fluid regulation, and metabolism using from single cell to whole body and behavior. As the controlling factors, involvements of nervous system, endocrine system and the relationship with immune system were also covered.Themes studied include the relationship between total peripheral resistance and central venous pressure, regulation of skin blood flow during local heating, the relationship between skin blood flow and sympathetic nervous activity, fever and the regional response of sympathetic nervous activity, the effect of gangliocides on the thermogenesis of brown adipose tissue, the effects of peptides and cytokines on the regulation of body fluid and circulatory functions, the effects of LPS, IL-1 and heat stress on the activity of macrophage, the role of catecholamine in CNS on circadian rhythm, the role of limbic system on space recognition, and the morphological changes of nerve cell due to ECF changes.Scientific meetings were held twice during the research period, and based on the presentations of these research works, lively discussions were made on the integrative view of these adaptive responses to environmental stress, interactions of these responses, the hierarchic structure of adaptive functions, and the control mechanism of these adaptive changes.The discussion was very stimulating to each member of the group, and will have feedback effects on their work and also to the environmental physiologists through their published works.