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Study on new risk factors for prevention of stroke and coronary heart disease in uged populations

老年人群脑卒中和冠心病预防新危险因素研究

基本信息

批准号：
02454209
负责人：
SHIMAMOTO Takashi
金额：
$ 4.35万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1992
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02454209/
关键词：
Fibrinogen Fatty acids composition Cerebral infarction Coronary heart disease Smoking Fish intake フィブリノ-ゲン

项目摘要

1. We examined plasma fibrinogen for 8,142 men and women aged 40-69 years in six urban and rural populations to investigate constitutional and lifestyle variables of plasma fibrinogen. Mean plasma fibrinogen was higher with age, higher in women than in men, and higher in those with a lower fish intake than in those with a higher fish intake. The variation in population levels of plasma fibrinogen was partly, but not fully explained by differences in those environmental factors.2. According to a comparative study of Japanese (n = 150) and US Caucasians (n =150), mean plasma fibrinogen was lower in Japanese than in Caucasians. The proportion of B2 allele on the beta-fibrinogen gene which was associated with higher plasma fibrinogen level, was higher in Caucasians than in Japanese.3. The variation in population levels of tissue plasminogen activator and plasminogen activator inhibitor according to a preliminary study of six US and Japanese populations.4. A nested case-control study was conducted among 13,425 urban men to examine the relation between serum fatty acid compositions with subsequent coronary heart disease. There were 26 coronary heart disease,and the control was matched for each case according to population, sex and age. According to conditional logistic regression, systolic blood pressure, serum total cholesterol, serum glucose and smoking were positively associated with coronary heart disease. HDL-cholesterol was inversely associated with coronary heart disease. Serum omega-3 fatty acids was inversely and omega-6 fatty acids was positively associated with coronary heart disease although not statistically significant. The result suggests that the effect of serum fatty acids on the development of coronary heart disease is smaller than that of conventional coronary risk factors. No association was found between serum fatty acids and cerebral infarction. Further follow-up will be conducted to confirm these associations.

1.我们检测了6个城市和农村人群中8,142名年龄在40-69岁的男性和女性的血浆纤维蛋白原，以调查血浆纤维蛋白原的体质和生活方式变量。平均血浆纤维蛋白原随年龄增长而升高，女性高于男性，且鱼摄入量较低的人高于鱼摄入量较高的人。人群中血浆纤维蛋白原水平的变化部分是由这些环境因素的差异造成的，但不能完全解释。根据对日本人(n=150)和美国高加索人(n=150)的比较研究，日本人的平均血浆纤维蛋白原低于高加索人。与血浆纤维蛋白原水平相关的β-纤维蛋白原基因上的B2等位基因在高加索人群中的比例高于日本人。根据对六个美国和日本人群的初步研究，组织纤溶酶原激活物和纤溶酶原激活物抑制物在人群水平上的变化。在13,425名城市男性中进行了一项嵌套式病例对照研究，以检查血清脂肪酸组成与随后发生的冠心病的关系。冠心病患者26例，按人口、性别、年龄配对。条件Logistic回归分析显示，收缩压、血清总胆固醇、血糖、吸烟与冠心病呈正相关。高密度脂蛋白-胆固醇与冠心病呈负相关。血清omega-3脂肪酸与冠心病呈负相关，omega-6脂肪酸与冠心病呈正相关，尽管在统计学上没有统计学意义。结果提示，血清脂肪酸在冠心病发生发展中的作用小于传统的冠心病危险因素。未发现血清脂肪酸与脑梗塞之间存在关联。将进行进一步的后续行动，以确认这些联系。