Study on new risk factors for prevention of stroke and coronary heart disease in uged populations

1.我们检测了6个城市和农村人群中8,142名40-69岁的男性和女性的血浆纤维蛋白原，以调查血浆纤维蛋白原的体质和生活方式变量。平均血浆纤维蛋白原随年龄增长而升高，女性高于男性，鱼类摄入量较低者高于鱼类摄入量较高者。血浆纤维蛋白原的人群水平的变化部分地但不能完全由这些环境因素的差异来解释.根据日本人（n = 150）和美国白人（n =150）的比较研究，日本人的平均血浆纤维蛋白原低于白人。与血浆纤维蛋白原水平升高相关的β-纤维蛋白原基因B2等位基因在白种人中的比例高于日本人.组织型纤溶酶原激活物和纤溶酶原激活物抑制物的人群水平的变化根据六个美国和日本人群的初步研究.对13，425名城市男性进行了巢式病例对照研究，以检查血清脂肪酸组成与随后的冠心病之间的关系。冠心病组26例，按人群、性别、年龄配对。经条件Logistic回归分析，收缩压、血清总胆固醇、血糖、吸烟与冠心病呈正相关。高密度脂蛋白胆固醇与冠心病呈负相关。血清ω-3脂肪酸与冠心病呈负相关，ω-6脂肪酸与冠心病呈正相关，但无统计学意义。结果提示，血清脂肪酸对冠心病发生发展的影响小于传统的冠心病危险因素。血清脂肪酸与脑梗死无相关性。将进行进一步的随访，以确认这些关联。

1. We examined plasma fibrinogen for 8,142 men and women aged 40-69 years in six urban and rural populations to investigate constitutional and lifestyle variables of plasma fibrinogen. Mean plasma fibrinogen was higher with age, higher in women than in men, and higher in those with a lower fish intake than in those with a higher fish intake. The variation in population levels of plasma fibrinogen was partly, but not fully explained by differences in those environmental factors.2. According to a comparative study of Japanese (n = 150) and US Caucasians (n =150), mean plasma fibrinogen was lower in Japanese than in Caucasians. The proportion of B2 allele on the beta-fibrinogen gene which was associated with higher plasma fibrinogen level, was higher in Caucasians than in Japanese.3. The variation in population levels of tissue plasminogen activator and plasminogen activator inhibitor according to a preliminary study of six US and Japanese populations.4. A nested case-control study was conducted among 13,425 urban men to examine the relation between serum fatty acid compositions with subsequent coronary heart disease. There were 26 coronary heart disease,and the control was matched for each case according to population, sex and age. According to conditional logistic regression, systolic blood pressure, serum total cholesterol, serum glucose and smoking were positively associated with coronary heart disease. HDL-cholesterol was inversely associated with coronary heart disease. Serum omega-3 fatty acids was inversely and omega-6 fatty acids was positively associated with coronary heart disease although not statistically significant. The result suggests that the effect of serum fatty acids on the development of coronary heart disease is smaller than that of conventional coronary risk factors. No association was found between serum fatty acids and cerebral infarction. Further follow-up will be conducted to confirm these associations.