Epidemiology and moleculorbiology on emvircnemnted and genetic factors for atheis sclirosis and thrombasis

动脉粥样硬化和血栓形成的环境因素和遗传因素的流行病学和分子生物学

• 批准号: 06454234
• 负责人: SHIMAMOTO Takashi
• 金额: $ 4.03万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06454234/
• 关键词: Plasma fibrinogen; Sernm total cholesterol; Epidemiologic study; Environmental factors; Genetic factors; DNA polymorphism; Coronary heart disease; Stioke; 心筋梗塞

Cross-sectional and cohort studies on serum total cholesterol and plasma fibrinogen, putative risk factors for cerebral infarction and coronary heart disease were conducted in Japanese residents of rural and urban communities, urban employees and Minnesota Caucasian residents to extract major environmental and genetic factors for cholesterol and fibrinogen, and to examine contribution of these factors to the development of cardiovascular disease. The follow are principal results.1. Major correlates for plasma fibrinogen was age, smoking, female in postive association, and seafood intake in inverse association.2. The prevalence of B2, H2, and Hd2 alleles of beta-fibrinogen were lower in Japanese than in Caucasians. Within each population, plasma fibrinogen was higher in these with B2, H2 and Hd2 alleles than in those without them. A lower prevalence of these genetic factors and a high intake of fish contributed in part to a lower mean of plasma fibrinogen in Japanese than in Caucasians. … More 3. R2 allele of Apo B polymorphism was associated with a lower concentration of serum total cholesterol. The prevalence of R2 allele was, however, lower in Japanese than in Caucasians. Thus, a lower serum cholesterol level in Japanese than in Caucasians was not explained by race difference in this polymorphism. Among Japanese, serum cholesterol levels will rise further with westernization of diet because of the lower prevalence of R2 allele.4. According to a case-control study of myocardial infarction among Osaka residents, plasma fibrinogen was associated with the risk of myocardial infarction as did serum total cholesterol, hypertension and cigarette smoking.5. According to a cohort study in rural and urban residents, plasma fibrinogen was positively associated with the risk of subsequent cerebral infarction and coronary heart disease. Serum total cholesterol was associated with the risk of coronary heart disease, but not with the risk of cerebral infarction. Among urban male employees, serum total cholesterol was associated with the risk of both cerebral infarction and coronary heart disease. Less

在日本农村和城市社区居民、城市雇员和明尼苏达州白人居民中进行了关于血清总胆固醇和血浆纤维蛋白原（脑梗死和冠心病的假定危险因素）的横断面和队列研究，以提取胆固醇和纤维蛋白原的主要环境和遗传因素，并检查这些因素对心血管疾病发展的贡献。主要结果如下：1.血浆纤维蛋白原的主要相关因素是年龄、吸烟、女性（正相关）和海鲜摄入量（负相关）.日本人β-纤维蛋白原的B2、H2和Hd2等位基因的患病率低于高加索人。在每个人群中，血浆纤维蛋白原在这些B2，H2和Hd2等位基因高于那些没有他们。较低的患病率，这些遗传因素和高摄入量的鱼的部分原因是较低的平均血浆纤维蛋白原在日本人比高加索人。 ...更多信息 3.载脂蛋白B多态性R2等位基因与血清总胆固醇浓度降低相关。然而，日本人R2等位基因的患病率低于高加索人。因此，日本人的血清胆固醇水平低于高加索人，不能用这种多态性的种族差异来解释。在日本人中，由于R2等位基因的低流行率，随着饮食的西化，血清胆固醇水平将进一步升高.根据大坂居民心肌梗死的病例对照研究，血浆纤维蛋白原与心肌梗死的风险相关，血清总胆固醇、高血压和吸烟也是如此。根据一项在农村和城市居民中进行的队列研究，血浆纤维蛋白原与随后发生脑梗死和冠心病的风险呈正相关。血清总胆固醇与冠心病的风险相关，但与脑梗死的风险无关。在城市男性职工中，血清总胆固醇与脑梗死和冠心病的危险性相关。少

项目成果

磯博康,嶋本喬: "循環器疾患予防へのアプローチ-虚血性疾患予防へのアプローチ" 公衆行生. 59. 840-843 (1995)

Hiroyasu Iso、Takashi Shimamoto：“预防心血管疾病的方法 - 预防缺血性疾病的方法”Kosei Yukio。59. 840-843 (1995)。

Iso H. Folson AR. Winkelami JC. Koike K. Harada S. Greanberg B.Sato S. Shimamoto T. Iida M. Komachi Y.: "Polymerphisme of the Bite fibrinogen gene and plasma fibrinogen concentration in Caucasians and Japanese Population sample" Thrombosis and Haemostasis

伊索·H·福尔森 AR。

磯博康 嶋本喬 小池和子 山海知子 今野弘規 佐藤真一 飯田稔 梅村詩子 小町育男: "血清脂質、脂肪酸、血液凝固線溶系因子と循環器疾患に関する疫学的研究" 日本循環器管理研究協議会誌. 30. 99-103 (1995)

Hiroyasu Iso、Takashi Shimamoto、Kazuko Koike、Tomoko Sankai、Hiroki Konno、Shinichi Sato、Minoru Iida、Umemura Umemura 和 Ikuo Komachi：“血清脂质、脂肪酸、凝血和纤溶因子以及心血管疾病的流行病学研究”杂志日本心血管管理研究委员会 30. 99 -103 (1995)。

Iso H,Fobrom AR,Winkelmann JC,Koike K,Harada S,Grecnberg B,Sato S,Shimamoto T,Iida M,Komachi Y: "Polymorphisms of the beta-fibrinojen geae and fibrinogen conentration in carcaseams and Japanese population" Thromb Haemost. 73. 106-111 (1995)

Iso H、Fobrom AR、Winkelmann JC、Koike K、Harada S、Grecnberg B、Sato S、Shimamoto T、Iida M、Komachi Y：“胴体和日本人群中 β-纤维蛋白原的多态性和纤维蛋白原浓度”血栓 Haemost。

Sato S Isi H. Naito Y. Kigawa M. Iida M. Shimamoto T. Komachi Y.: "Plasma fibrinogen and its conelates in urban Japanese men" International Journal of Epidemiology. (in press). (1996)

Sato S Isi H. Naito Y. Kikawa M. Iida M. Shimamoto T. Komachi Y.：“日本城市男性中的血浆纤维蛋白原及其相关物”国际流行病学杂志。