Epidemiological study on carotid atherosclerosis and it related factors for the prevention of cardiovascular disease

颈动脉粥样硬化及其相关因素的流行病学研究及其预防心血管疾病的研究

• 批准号: 08457125
• 负责人: SHIMAMOTO Takashi
• 金额: $ 4.99万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457125/
• 关键词: Cardiovascuilar; carotid sonography; risk factors; prevention; plasma fibrinogen; prospective stady; screening

We applied carotid sonography to cardiovascular risk surveys to detect high risk individuals of ishemic stroke and heart disease and to achieve their prevention. The surveyed populations were northeast rural, southwest, and central rural communities and Osaka urban suburbs and urban employees. The incidence of ischemic stroke was high in northeast rural community, intermediate in southwest and central rural communities, and low in rural suburbs and employees. The incidence of ischemic heart disease was higher in urban employees than in the other populations. Carotid sonography was conducted in 1,286 men aged 50-74, and examined the relations with conventional cardiovascular risk factors and plasma fibrinogen. The proportion of a high mean intima-medial complex and/or multiple plaques was higher in northeast rural community than in other populations, which corresponded with the higher blood pressure levels and the higher incidence of ischemic stroke. Carotid atherosclerosis was associated with low HDL-cholesterol levels, smoking, diabetes mellitus, but not related with serum total cholesterol or alcohol intake.Plasma fibrinogen was higher among the patients of ischemic heart disease than among controls. Prospective study of 1,1920 men and women aged 40 and over confirmed that plasma fibrinogen was an independent risk factor for ischemic heart disease. These results support the usefulness of carotid sonogaphy to predict the risk of ischemic cardiovascular disease.

我们将颈动脉超声应用于心血管风险调查，以检测缺血性中风和心脏病的高危个体，并实现他们的预防。调查对象为东北农村、西南农村和中部农村社区以及大阪市郊和城市雇员。东北农村社区缺血性卒中发病率较高，西南部和中部农村居中，郊区和从业人员发病率较低。城市雇员的缺血性心脏病发病率高于其他人群。对1,286例50~74岁男性进行颈动脉超声检查，探讨其与常规心血管危险因素及血浆纤维蛋白原的关系。东北农村高平均内膜-中膜复合体和/或多发斑块的比例高于其他人群，这与高血压水平和缺血性卒中的发病率较高相对应。颈动脉粥样硬化与低高密度脂蛋白水平、吸烟、糖尿病有关，与血清总胆固醇、饮酒无关。缺血性心脏病患者血浆纤维蛋白原水平高于对照组。对11920名年龄在40岁及以上的男性和女性进行的前瞻性研究证实，血浆纤维蛋白原是缺血性心脏病的独立危险因素。这些结果支持颈动脉声像图在预测缺血性心血管疾病风险方面的有效性。

项目成果

Sato S, Iso H, Naito Y, Kiyama A, Ii-da M, Shimamoto T, Komachi Y.: "Plasma fibrinogen and its correl-ates in urban Japanese men." Int J Epidemiol. 25. 521-527 (1996)

Sato S、Iso H、Naito Y、Kiyama A、Ii-da M、Shimamoto T、Komachi Y.：“日本城市男性的血浆纤维蛋白原及其相关物。”

Iso H.Shimamoto T.Sato S, Koike K, Iida M, Komachi Y.: "Pssive Smoking and plasma fibrin-ogen concentrations." Am J Epidemiol. 144. 1551-1154 (1996)

Iso H.Shimamoto T.Sato S、Koike K、Iida M、Komachi Y.：“被动吸烟和血浆纤维蛋白原浓度。”

万波俊文・飯田稔・嶋本喬、他: "高解像度頸部超音波検査による動脈硬化所見の地域比較-農村部と都市部の一般住民の比較検討-" 日本公衆衛生雑誌. 43. 286 (1996)

Toshifumi Manami、Minoru Iida、Takashi Shimamoto 等人：“高分辨率颈部超声检查的动脉硬化结果的区域比较 - 农村和城市地区一般人群的比较研究 -”日本公共卫生杂志 43. 286（1996 年）。 ）

Sato S,Kitamura A,Iida M,et al: "A-Case-Reference Study on Plasma Fibrinogen Concentrations and Coronary Atherosclerosis in Japanese" Journal of Epidemiology. 6. 81-86 (1996)

Sato S，Kitamura A，Iida M，等：“日本血浆纤维蛋白原浓度和冠状动脉粥样硬化的案例参考研究”流行病学杂志。