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Recent change of Risk factors of Ischemic Cordio-and Cerebrovasular Diseases

缺血性心脑血管疾病危险因素近期变化

基本信息

批准号：
04304036
负责人：
SHIMAMOTO Takashi
金额：
$ 8.96万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1994
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04304036/
关键词：
Lacunar infarction Thrombeembolic infarction Risk factors Cohort study Serum fatty acids Plasma fibrinogen Tissue plasminogen Asymptomatic infarction 脳卒中虚血性心疾患脳塞栓皮真性脳血栓

项目摘要

The data from a long-term epidemiologic studies in populations in ibaraki, Akita, Osaka, Kochi, Hiroshima, Nagasaki, Fukuoka was analyzed and the following results were obtained.1) The proportion of cerebral infarction among total stroke increased in each population. According to computer tomography (CT) findings, the proportion was highest in lacunar infarction, and progressively lower in embolic infarction and in thrombotic infarction. The proportion of lacunar infarction was higher in Japanese populations than in Western populations. Incidence of ischemic heart disease has increased in urban male employees, but has not changed in other populations.2) A cohort of 25,811 men and women aged 40-69 was followed 9 to 10 years and 779 stroke and 307 ischemic heart disease incidence cases were obtained. Significant risk factors shown by regression analyzes were hypertension for lacunar infarction, high serum total cholesterol, alcohol intake, left ventricular hypertrophy for thrombotic infa … More rction, and atrial infarction and left ventricular hypertrophy for embolic infarction. Risk factors for ischemic heart disease were high serum total cholesterol, high blood pressure, and cigarette smoking.3) According to a prospective nested case-control study in rural populations, the proportion of serum polyunsaturated fat, in particular n-6 fatty acids was lower in stroke incidence cases, either hemorrhagic or non-hemorrhagic stroke than in controls.In urban populations, the proportion of n-3 fatty acids tended to be lower in ischemic heart disease cases than in controls. Plasma fibrinogen concentrations were higher in patients of ischemic heart disease than in control.4) Related factors for serum fatty acids, plasma fibrinogen and tissue plasminogen activator inhibitor I included cigarette smoking, alcohol intake and fish intake.Pathologic study showed that a probable cause of vascular dementia was nonsymptomatic lacunar infartion in basal ganglia which was acceralated by aging and hypertension. Less

对茨木、秋田、大坂、高知、广岛、长崎、福冈等地长期流行病学调查资料进行分析，结果表明：（1）各地区脑梗死在总卒中中所占比例均呈上升趋势。根据计算机断层扫描（CT）结果，腔隙性梗死的比例最高，栓塞性梗死和血栓性梗死的比例逐渐降低。日本人群中腔隙性梗死的比例高于西方人群。2）对25,811名40-69岁的男性和女性进行了9 ~ 10年的随访，获得779例脑卒中和307例缺血性心脏病发病病例。回归分析显示，高血压、高血清总胆固醇、饮酒、左心室肥厚、血栓性梗死、高血压、高胆固醇、高血压、高胆固醇、高血压、高血压、高胆固醇、高血压、高血压、高胆固醇、高血压、高血压、高胆固醇、高血压、高胆固醇、高血压 ...更多信息心房梗死和左心室肥大用于栓塞性梗死。缺血性心脏病的危险因素是高血清总胆固醇、高血压和吸烟。3）根据一项在农村人群中进行的前瞻性巢式病例对照研究，血清多不饱和脂肪酸的比例，特别是n-6脂肪酸在卒中发病病例中的比例，无论是出血性还是非出血性卒中，均低于对照组。在城市人群中，n-3脂肪酸的比例在缺血性心脏病病例中倾向于低于对照组。缺血性心脏病患者血浆纤维蛋白原浓度高于对照组; 4）吸烟、饮酒、食鱼等与血清脂肪酸、血浆纤维蛋白原和组织型纤溶酶原激活物抑制物I有关。病理学研究表明，无症状的基底节区腔隙性脑梗死是血管性痴呆的一个可能原因，而年龄增长和高血压则加速了这一过程。少