Intestinal motility of autograft and allograft after extensive small bowel resection.

广泛小肠切除术后自体移植物和同种异体移植物的肠动力。

• 批准号: 02454314
• 负责人: UCHIYAMA Masanori
• 金额: $ 3.52万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02454314/
• 关键词: Bowel Resection; Intestinal Motility; Jejunal Reversed Segment; Intestinal Implantation; 逆蠕動性小腸吻合術; 小腸運動; 筋電図

The present experiment was designed to study the feasibility of intestinal autograft and allograft by clarifying the intestinal motility after extensive intestinal resection in dogs. The intestinal motility was continuously measured by using the electrodes and/or force transducers in interdigestive and postprandial conscious dogs at 2 to 5 weeks after surgery.Three dog models and the control were prepared. 1 ; Extensive small bowel resection(ESBR), 80% distal small bowel resection followed jejunoileal anastomosis was performed. 2 ; A 20-cm segment at the end of remnant jejunum was reversed after ESBR(Reversed JeJunum + ESBR), and then jejunojenunostomy and jejunoileostomy was performed. 3 ; A 20-cm jejunal allograft was implanted in the host-dog by anastomosing mesenteric vessels after ESBR, the allograft was isolated from the fiost intestifie. My oelectric electrodes and strain gage force transducers were implanted in the duodenum, the proximal jejunum, the Jejunum above anastomosis, … More terminal ileum and the reversed jejunum or the allograft.Result : l ; ESBR, the fasting duodenal myoelectric(or motor.)complex(MMC)occurred at longer intervals. The propagation incidence of the duodenal MMCs to the terminal ileum'was decreased. propagation velocity of the MMCs was slower at the duodenum to the jejunum and to the terminalileum. The duration of the postprandial period without duodenal MMC activity was significantly prolonged. 2 ; ESBR+Reversed Segment, the duodenal MMC interval was markedly longer. The short and small contractions were repeatedly discordant in the reversed segment and the jejunum above the anaktomosis. The propagation pattern of the duodenal MMCs werd dominantly followed the inherent preoperative anatomical continuity. 3 ; ESBR+Allograft, the intestinal motility at both host intestine'and allograft jejunum was very small and irregular, and-independent each other in short term postoperatively. The motility could not measured by the problem related to the vessel occlusion and infection.Conclusion : The compensatory motility for accelerated transit time after extensive small bowel resection appeared in early postoperative period. Functional obstruction is the potential problem in 20-cm reversed jejunal segment after ESBR. More technical and careful treatment are needed in the intestinal implantation after ESBR. Less

本实验旨在通过研究犬广泛肠切除后的肠道运动，探讨自体和同种异体肠移植的可行性。术后2~5周用电极和(或)力传感器连续测定清醒犬和消化间期清醒犬的肠动力。1.广泛小肠切除(ESBR)，80%远端小肠切除后空回肠吻合术。2.ESBR(反转空肠+ESBR)后，在残肠末端20 cm处翻转，然后行空肠吻合术和空肠吻合术。3.ESBR后，通过吻合肠系膜血管将20 cm同种异体空肠移植到宿主犬体内，将异体空肠移植物从第一肠段分离出来。我的光电电极和应变力传感器被植入十二指肠、空肠近端、吻合口上方的空肠，…结果：L：空腹十二指肠肌电(或运动)复合波出现间隔较长。十二指肠MMCs向回肠末端的传播率降低。MMCs在十二指肠、空肠和回肠的传播速度较慢。无十二指肠MMC活动的餐后持续时间显著延长。ESBR+反转节段，十二指肠MMC间期明显延长。反位段和空肠上段短而小的收缩反复出现不协调。十二指肠MMCs的增殖模式主要遵循术前固有的解剖连续性。3、ESBR+异体肠移植，术后短期内宿主肠和同种异体空肠的运动均很小且不规则，且相互独立。结论：广泛小肠切除术后早期出现代偿性通过时间缩短的代偿性运动。功能性梗阻是ESBR术后20 cm逆行空肠段的潜在问题。ESBR术后的肠道植入需要更多的技术和细致的治疗。较少

项目成果

Uchiyama Masanori, Iwafuchi Makoto, et al: "Intestinal motility in dogs with a reversed jejunal segment after extensive small bowel resection" Jpn J Smooth Muscle Res. 27, No 4. (1991)

Uchiyama Masanori、Iwafuchi Makoto 等人：“广泛小肠切除术后空肠段反向的狗的肠蠕动”Jpn J Smooth Muscle Res。

内山 昌則,岩渕 眞,他: "小腸大量切除・逆転吻合術後の小腸運動" 日本平滑筋学会雑誌. 27. (1991)

Masanori Uchiyama、Makoto Iwabuchi 等人：“大规模小肠切除和反转吻合术后的小肠运动”，日本平滑肌学会杂志 27。（1991）

八木 実,内山 昌則,他: "小腸広範囲切除後の胆嚢運動に関する実験的研究(術後短期例での検討)" 日本平滑筋学会雑誌. 27. (1991)

Minoru Yagi、Masanori Uchiyama 等：“宽小肠切除术后胆囊运动的实验研究（短期术后病例的研究）”日本平滑肌学会杂志 27。（1991）。

Yagi Minoru, Uchiyama Masanori, et al: "Experimental study of gallbladder motility after massive intestinal resection." Jpn J Smooth Muscle Res. 27, No 4. (1991)

Yagi Minoru、Uchiyama Masanori 等人：“大肠切除术后胆囊运动的实验研究。”

Uchiyama Masanori, Iwafuchi Makoto, et al: "Intestinal myoelectric activity and contractile. motility in dogs with a reversed jejunal segment after extensive small bowel resection." J Pediatr Surg. 27, No 6. (1992)

Uchiyama Masanori、Iwafuchi Makoto 等人：“广泛小肠切除术后空肠段反向的狗的肠肌电活动和收缩运动。”