The physiological and pathological role of the bile acid receptor TGR5 and its potential targeting for the treatment of intestinal motility disorders and visceral pain.

胆汁酸受体 TGR5 的生理和病理作用及其治疗肠道动力障碍和内脏疼痛的潜在靶点。

• 批准号: nhmrc : 1053593
• 负责人: Dr Leni Rivera
• 金额: $ 20.79万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/physiological-pathological-role-visceral-pain/112336
• 关键词: physiological; pathological; role; bile; acid

Defects in the secretion of bile into the intestine cause digestive diseases, and abnormal circulating levels of bile acids induce profound itch and abnormal pain sensation. This project examines whether a cell-surface receptor (TGR5) produced by intestinal and sensory neurons mediates actions of bile acids on intestinal functions and pain. The project aims to define mechanisms of digestive and sensory disorders and identify new therapies for constipation, diarrhoea, and pain.

胆汁分泌到肠道中的缺陷会引起消化系统疾病，胆汁酸的异常循环水平会引起严重的瘙痒和异常的疼痛感。本项目研究由肠和感觉神经元产生的细胞表面受体（TGR 5）是否介导胆汁酸对肠功能和疼痛的作用。该项目旨在确定消化和感觉障碍的机制，并确定便秘，腹泻和疼痛的新疗法。