The motility and electorical activity of reconstructed intestine after biliary surgery.

胆道手术后重建肠道的蠕动和选举活动。

• 批准号: 60480300
• 负责人: UCHIYAMA Masanori
• 金额: $ 3.65万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480300/
• 关键词: Billiary reconstruction; Intestinal motility; 空腹期MMC; MMCの伝播; 小腸筋電図; 小腸収縮曲線

To assess the post-operative motility of intestine, dogs were prepared for the biliary reconstruction. In our experiment, after ligation and resection of the common bile duct, the biliary tract was reconstructed by two different anastomosis; 1)40cm- jejunum resected at 40cm distal from treitz' ligament was interposed between gall- bladder and duodenum, 2)40cm-jejunal Roux-loop(40cm from Treitz' lig.) was anastomosed to the gall-bladder.To investigate the post-operative motility of intestine, contractile force transducers and bipolar electrodes were implanted in the serosal surface of the intestine one month to tne months following the first procedure. Motility of intestine was recorded continuously for a week in conscious state.Results: 1) Changes of the myoelectric activity revealed the good coincidence with those of the contractile activity. 2) The frequencies of the BER either in the reconstructed jejunum in both groups were less than those obtained in the more proximal jejunum. Thi … More s phenomenon was also observed long term period after the initial operation. 3) Cyclic interdigestive migrating myoelectric complex(MMC) which iniciate from duodenum was propagated normogradely even in the reconstructed intestine during the eary post- operative period. 4) Independent paticular motility was also found in the reconstructed jejunum. 5) After the long term period, changes in the pattern of the intestinal motility which were concidered to be an adaptive phenomenon for the operative procedure were observed.Conclusion: From the view point of intestinal motility in eary post-operative period, Roux-en Y anastomosis is judged to give more effective and smooth transport of the bile juice from the hepatic port to distal jejunum than interposion, because intestinal contents including the bile juice tend to stay in interposed jejunum. However, interposed jejunum gradually gains its adaptive motility and also can transport the bile to the duodenum efficiently on the long term period. Therefore, the results on own present study shows that we have to pay enough attention to ascending choleangitis paticularly in the biliary reconstruction by jejunal interposition technique, during the early post- operative period. Less

为了评估术后肠的运动能力，我们准备了胆道重建犬。本实验在结扎和切除胆总管后，采用两种不同的吻合方式重建胆道；1)在距treitz韧带远端40cm处切除40cm-空肠，在胆囊和十二指肠之间置入；2)在距treitz韧带远端40cm处，将40cm-空肠Roux-loop与胆囊吻合。为了研究肠的术后运动，在第一次手术后1至3个月，在肠浆膜表面植入收缩力传感器和双极电极。在清醒状态下连续记录肠道运动一周。结果：1)肌电活动的变化与收缩活动的变化具有较好的一致性。2)两组重建空肠的BER频率均低于较近端空肠。这种现象在初次手术后的很长一段时间内也能观察到。3)在术后早期重建肠内，始自十二指肠的循环消化间迁移肌电复合体（MMC）也能正常繁殖。4)重建空肠也有独立的特殊运动性。5)长期后观察到肠蠕动模式的变化，这被认为是对手术过程的适应性现象。结论：从术后早期肠道运动的角度来看，Roux-en - Y吻合术比插入法更能有效、顺畅地将肝口胆汁液输送到远端空肠，因为包括胆汁液在内的肠内容物倾向于停留在插入空肠。但间接性空肠逐渐获得适应运动能力，并能长期有效地将胆汁转运至十二指肠。因此，本研究的结果表明，在术后早期，特别是空肠介入技术胆道重建时，我们必须对上升胆管炎给予足够的重视。少

项目成果

高野邦夫: 日本平滑筋学会雑誌. 22. 170-174 (1986)

Kunio Takano：日本平滑肌学会杂志 22. 170-174 (1986)。

Kunio Takano,: "Motility of intestine in biliaruy reconstruction by jejunal interposition." Jpn.J.Smooth Muscle Res.23. 258-262 (1987)

Kunio Takano，：“空肠介入胆道重建中肠道的运动。”

内山昌則: 日本平滑筋学会雑誌. 22. 174-177 (1986)

Masanori Uchiyama：日本平滑肌学会杂志 22. 174-177 (1986)。

Masanori Uchiyama: "Intestinal motility of Roux-loop in biliary reconstruction by Roux-en Y anastomosis." Jpn.J.Smooth Muscle Res.21. 186-188 (1985)

Masanori Uchiyama：“Roux-en Y 吻合术胆道重建中 Roux-loop 的肠蠕动。”

Kunio Takano: "Intestinal motility of biliary reconstruction by jejunal interposition in long term period." Jpn.J.Smooth Muscle Res.21. 360-362 (1985)

Kunio Takano：“长期空肠介入重建胆道的肠动力。”