Development of Er-YAG laser for laser angioplasty

用于激光血管成形术的 Er-YAG 激光器的开发

• 批准号: 02454327
• 负责人: OKAMOTO Yoshifumi
• 金额: $ 3.14万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02454327/
• 关键词: Erbium-YAG; laser; laser fiber; Zirconium-Fglass; coronal angioplasty; マルチファイバ-システム; ロングパルスエキシマレ-ザ-; 動脈狭窄性病変; アテロ-ム蒸散; ErーYAGレ-ザ-; Angioplasty; 動脈硬病変; エキシマレ-ザ-

Result of developments of Er-YAG laser and its delivery system were reported. Er-YAG laser's wavelength is 2.94 mu m, the beam absorption rate by water is higher than other laser beam. Er-YAG laser beam is expected different effect for a biotissue. Er-YAG laser has repeated pulse oscillation, pulse width is 240 mu, sec, the repeat frequency is between 5 to 10 pulse per second. The mean power is 4w maximum, 10pps.The fiber's of laser are made of zirconium-F-glass.We carried out a study on the possible application of the Er-YAG laser on the rabbit arteries and myocardium and human arteries were examined in vitro. Very clear cuts were observed on the histological examination. There were no evidence of thermal damage, no carbonization on the sharp catting surface. Experimental result showed that Er-YAG lasers had good potential for angioplastic laser.

本文报道了Er-YAG激光器及其传输系统的研制结果。Er-YAG激光器的波长为2.94 μ m，水对激光束的吸收率高于其它激光束。预期Er-YAG激光束对生物组织有不同的作用。Er-YAG激光器具有重复脉冲振荡，脉冲宽度为240 μ s，重复频率为5 ~ 10脉冲/秒。激光器的平均功率为4 W，最大功率为10 ps，光纤采用锆F玻璃，我们对Er-YAG激光在离体兔动脉、心肌和人动脉上的应用进行了研究。在组织学检查中观察到非常清晰的切口。没有热损伤的迹象，锋利的表面上没有碳化。实验结果表明，Er-YAG激光在血管成形激光方面具有良好的应用前景。

项目成果

小林 彰: "Er-YAGレーザーの基礎的研究" 日本心臓血管外科学会誌. 19. 995-997 (1990)

Akira Kobayashi：“Er-YAG 激光的基础研究”日本心血管外科学会杂志 19. 995-997 (1990)。

岡本 好史: "冠動脈外科におけるレーザーの開発" 日本外科宝凾. 59. 435-437 (1990)

Yoshifumi Okamoto：“冠状动脉手术中激光的发展”日本外科杂志 59. 435-437 (1990)。

Yoshifumi Okamoto: "Development of Er-YAG Laser Angioplasty" Arch Jpn Chir. (1993)

Yoshifumi Okamoto：“Er-YAG 激光血管成形术的发展”Arch Jpn Chir。

荻野 均: "ロングパルスエキシマレーザーの組織蒸散能およびファイバー尊光に関する研究" 日本レーザー医学会誌. 12. 3-10 (1991)

Hitoshi Ogino：“长脉冲准分子激光的组织消融能力和纤维吸收的研究”日本激光医学会杂志12. 3-10（1991）。

岡林 均: "エキシマレーザーを用いたLaser Angioplasty" 日本レーザー医学会誌. 10. 331-333 (1989)

Hitoshi Okabayashi：“使用准分子激光的激光血管成形术”日本激光医学会杂志 10. 331-333 (1989)。