CONTROLLED RELEASE OF DRUG BY MEMBRANE OF STIMULISENSITIVE POLYMER GEL

通过刺激敏感聚合物凝胶膜控制药物释放

• 批准号: 03453124
• 负责人: NAKANO Yoshio
• 金额: $ 4.35万
• 依托单位: TOKYO INSTITUTE OF TECHNOLOGY (1992-1993)Shizuoka University (1991)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03453124/
• 关键词: POLYMER GEL; DRUG DELIVERY SYSTEM; CONTROLLED RELEASE; HYDROPHILIC; HYDROPHOBIC; ADSORPTION; DESORPTION; ELECTRO-OXIDATIVE POLYMERIZATION; IONTOPHORESIS; CHARGE CONTROLLABLE MEMBRANE; イオン

Recently, reserches for the materials which control the release of drug inside themselves depending on the surrounding conditions have been attracting much attention because of their importance in many ( medical, pharmacy, agriculture, engineering) fields. In this reserch, the methods of release control of drug and its device design were studied in order to realize controlled release systems and establish its control methods. We obtained the folowing results from the viewpoint of both the physicochemical controlling method (system 1) and electrochemical controlling method (system 2).System 1 :The dependency of surface property (hydrophilic-hydrophobic balance) of thermosensitive N-isopropylacrylamide copolymer gels on the temperature was studied. These gels was found to have the potential for device which control the adsorption and desorption of organic matter onto them only by the temperature swing. We examined the effects of physicochemical structure of gel, solution pH, the hydrophi … More lic-hydrophobic balance of adsorbent and the structure of solution on the surface property of gel, and established the method of design for the device which had better adsorption property and mechanical strength.The shrinking mechanizm of gel was studied using ionic gel. The relationship between the transfer of ions through gel and shrinkage (solvent release) was well defined. The factors which control the release of solvent in the gel and the controlling method were mentioned in detail.System 2 :The method of controlling the surface property of thermosensitive polymer gel by electrochemical method were developed by means of the doping of weak acid group in the gel. The surface property of electrochemically controlled gel and its mechanizm were elucidated.The property of charge controllable membrane was studied to realize the control release of drug by iontophoresis using polypyrrol as membrane. It was found by the measurement of transport of drug in the membrane using quarts micro balance method that the permeation of drug through membrane can be easily controlled by the swing of electric potential which applied to the membrane. Less

近年来，由于药物在医学、制药、农业、工程等领域的重要作用，对依赖于环境条件控制药物释放的材料的研究引起了人们的极大关注。本研究对药物的释放控制方法及其装置的设计进行了研究，以期实现药物的控释系统，建立药物的控制方法。从物理化学控制法(系统1)和电化学控制法(系统2)两个角度研究了N-异丙基丙烯酰胺共聚凝胶的表面性质(亲水-疏水平衡)与温度的关系。这些凝胶被发现有可能成为仅通过温度变化来控制有机物在其上的吸附和解吸的装置。我们考察了凝胶的物理化学结构、溶液pH、疏水性…的影响吸附剂的疏水平衡和溶液的结构对凝胶表面性质的影响，确立了具有较好吸附性能和机械强度的装置的设计方法。离子通过凝胶的转移和收缩(溶剂释放)之间的关系被很好地定义。详细介绍了控制凝胶中溶剂释放的因素和控制方法。系统2：通过在凝胶中掺杂弱酸性基团，建立了电化学方法控制热敏聚合物凝胶表面性质的方法。阐述了电化学控制凝胶的表面性质及其作用机理，研究了以聚吡咯为膜的电荷可控膜的性质，以实现药物的离子导入控释。用夸茨微天平法测量药物在膜中的传递，发现药物的透膜可以很容易地通过施加在膜上的电势的摆动来控制。较少

项目成果

Y.Seida and Y.Nakano: "The Effect of pH on the Phase Transition of N-Isopropylacrylamide-Sodium Acrylate Copolymer Gel (投稿中)" J.Chemical Engineering Japan.

Y.Seida 和 Y.Nakano：“pH 对 N-异丙基丙烯酰胺-丙烯酸钠共聚物凝胶相变的影响（进行中）”J.Chemical Engineering Japan。

木下 修一,清田 佳美,中野 義夫: "有機物吸着における感温性ゲルの構造と塩添加の効果" 第6回高分子ゲル研究討論会講演要旨集. 18-19 (1992)

Shuichi Kinoshita、Yoshimi Kiyota、Yoshio Nakano：“热敏凝胶的结构以及盐添加对有机物吸附的影响”第六届聚合物凝胶研究会议摘要18-19（1992）。

M.Sudoh,K.Minamoto et al.: "Transport Properties of Anion-Exchange Menbrane Prepared for Producing Hydrogen Peroxide in Acidic Solutions by Electrodialys of Peroxide Ions." J.Chemical Engineering Japan. 25. 170-176 (1992)

M.Sudoh、K.Minamoto 等人：“通过过氧化离子电渗析在酸性溶液中生产过氧化氢而制备的阴离子交换膜的传输特性”。

Yoshimi Seids,Yoshio Nakano: "Adsorption properties of organic matter onto temperatureーsensitive Nーisopropylacrylamide gel" Proceeding of the Second ChinaーJapanーUSA Symposium on Advanced Adsorption Separation Science and Technology. 2-4 (1991)

Yoshimi Seids，Yoshio Nakano：“有机物在温度敏感的N异丙基丙烯酰胺凝胶上的吸附特性”第二届中日美先进吸附分离科学与技术研讨会论文集2-4（1991）。

Y.Seida: "Transport of ions inside polymer gel in an electric field" J.Chem.Eng.Japan. 24. 755-760 (1991)

Y.Seida：“电场中聚合物凝胶内离子的传输”J.Chem.Eng.Japan。