CONTROLLED RELEASE OF DRUG BY MEMBRANE OF STIMULISENSITIVE POLYMER GEL

近年来，根据周围环境条件控制药物在其内部释放的材料的研究因其在许多领域（医学、药学、农业、工程）中的重要性而备受关注。本研究对药物的释放控制方法及装置设计进行了研究，以实现药物的控释系统，建立药物的控释方法。从物理化学控制方法（系统1）和电化学控制方法（系统2）的角度得到了以下结果：体系1：研究了热敏型n -异丙基丙烯酰胺共聚物凝胶的表面性能（亲疏水平衡）与温度的关系。研究发现，这些凝胶具有仅通过温度变化来控制有机物质在其上的吸附和解吸的潜力。考察了凝胶的理化结构、溶液pH、吸附剂的疏水平衡、溶液结构等因素对凝胶表面性能的影响，建立了具有较好吸附性能和机械强度的装置设计方法。用离子凝胶研究了凝胶的收缩机理。离子通过凝胶的转移与收缩（溶剂释放）之间的关系得到了很好的定义。详细介绍了凝胶中溶剂释放的影响因素及控制方法。体系二：通过在凝胶中掺杂弱酸基团，研究了电化学控制热敏聚合物凝胶表面性能的方法。阐述了电化学控制凝胶的表面性质及其作用机理。以聚吡咯为膜，研究了电荷可控膜的性能，实现了药物的离子电泳控释。用石英微天平法测定了药物在膜内的输运，发现药物通过膜的渗透可以通过施加在膜上的电位的摆动来控制。少

Recently, reserches for the materials which control the release of drug inside themselves depending on the surrounding conditions have been attracting much attention because of their importance in many ( medical, pharmacy, agriculture, engineering) fields. In this reserch, the methods of release control of drug and its device design were studied in order to realize controlled release systems and establish its control methods. We obtained the folowing results from the viewpoint of both the physicochemical controlling method (system 1) and electrochemical controlling method (system 2).System 1 :The dependency of surface property (hydrophilic-hydrophobic balance) of thermosensitive N-isopropylacrylamide copolymer gels on the temperature was studied. These gels was found to have the potential for device which control the adsorption and desorption of organic matter onto them only by the temperature swing. We examined the effects of physicochemical structure of gel, solution pH, the hydrophi … More lic-hydrophobic balance of adsorbent and the structure of solution on the surface property of gel, and established the method of design for the device which had better adsorption property and mechanical strength.The shrinking mechanizm of gel was studied using ionic gel. The relationship between the transfer of ions through gel and shrinkage (solvent release) was well defined. The factors which control the release of solvent in the gel and the controlling method were mentioned in detail.System 2 :The method of controlling the surface property of thermosensitive polymer gel by electrochemical method were developed by means of the doping of weak acid group in the gel. The surface property of electrochemically controlled gel and its mechanizm were elucidated.The property of charge controllable membrane was studied to realize the control release of drug by iontophoresis using polypyrrol as membrane. It was found by the measurement of transport of drug in the membrane using quarts micro balance method that the permeation of drug through membrane can be easily controlled by the swing of electric potential which applied to the membrane. Less