Hyperplasia of distal airway epithelium due to aging among residents in the area where the incidence of lung cancer is high.

肺癌高发地区居民因老龄化导致远端气道上皮增生。

• 批准号: 03454165
• 负责人: HAYASHI Yutaka
• 金额: $ 2.05万
• 依托单位: Institute of Pulmonary Cancer Research, Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03454165/
• 关键词: Lung Cancer; Prevailing Cancer; Hyperplasia; Proliferation; Dog; Okinawa; 核小体形成領域

(1) We scrutinized the histological changes of lungs obtained from surgical materials or autopsy cases of the people in Okinawa and Nagasaki where lung cancer is prevailing and compared them with that in Chiba where the incidence of lung cancer is relatively low. (2) The lungs from Okinawa had multiple hyperplastic foci of distal airway epithelium and its severity was great. (3) The incidence of hyperplastic foci was low among Chiba residents. Although the incidence of lung cancer among Nagasaki residents was high, the incidence of hyperplastic foci was as low as that among Chiba residents. Therefore, the high incidence of hyperplastic foci is specific not to the area where lung cancer is prevailing but to the lungs from Okinawa residents. (4) Although the origin of both hyperplastic foci and lung cancer is speculated to be proliferative epithelial cells, there was no histological evidence that the former was antecedent of the latter. Hyperplastic foci was observed more frequently in the lung of adenocarcinoma than in that of epidermoid carcinoma and atypical hyperplastic foci had close histological resemblance to adenocarcinoma. (5) Theseverity of hyperplasia was greater as the age of the people increased. This tendency was similar to the fact that the incidence of lung cancer becomes higher as the age of the patients increases. (6) We studied the changes of lungs of stray dogs in Okinawa, but lung cancer was rarely observed. However, hyperplastic foci were observed showing the possibility that there are external causes which are responsible for this change. We must examine the lungs of dogs in otherareas to prove this possibility. (7) There was no relationship between smoking and the occurrence of hyperplastic foci. Not only the importance of external causes but that of internal causes must be evaluated to clarify the reason of high incidence of lung cancer in Okinawa. We are now continuing the research focusing on the possible internal causes.

(1)我们对肺癌高发地区冲绳和长崎的手术材料或尸检病例中肺部的组织学变化进行了详细分析，并与肺癌发病率相对较低的千叶地区进行了比较。(2)冲绳人肺远端气道上皮多发增生性灶，严重程度高。(3)千叶县居民增生性病灶发生率较低。虽然长崎居民的肺癌发病率较高，但增生性病灶的发病率与千叶居民一样低。因此，增生性病灶的高发并不局限于肺癌流行的地区，而是冲绳居民的肺部。(4)虽然推测增生性灶和肺癌的起源都是增生性上皮细胞，但没有组织学证据表明前者先于后者。腺癌肺中增生性病灶较表皮样癌多见，非典型增生性病灶与腺癌有密切的组织学相似性。(5)随着年龄的增长，这种增生的严重程度更大。这种趋势与肺癌的发病率随着患者年龄的增长而增加的事实相似。(6)我们研究了冲绳流浪狗肺部的变化，但很少观察到肺癌。然而，观察到增生性病灶，表明可能有外部原因导致这种变化。我们必须检查其他地区狗的肺部来证明这种可能性。(7)吸烟与增生性病灶的发生无相关性。要弄清冲绳地区肺癌高发的原因，不仅要评估外因的重要性，还要评估内因的重要性。我们目前正在继续研究可能的内因。