Genetic analysis of glioblastoma cancer stem cell with special reference to chronological and spatial change

胶质母细胞瘤干细胞的遗传分析，特别参考时间和空间变化

• 批准号: 20591708
• 负责人: HAYASHI Yutaka
• 金额: $ 2.91万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591708/
• 关键词: 脳腫瘍; 神経膠芽腫; 腫瘍幹細胞; 神経膠芽腫瘍; 遺伝子異常

To evaluate the specific factors in tumorigenesis of the glioblastoma, especially in chronological and spatial character, several genes expressions and mutations were analyzed. Among the integrins that could be related with invasion, the alpha 3 subunit had a significantly higher expression level in tumor stem cells. The alpha 3 subunit of integrin could play an important role in the tumor invasion. Furthermore, during a course of tumor progression, FAS and TP53 mutation were detected. These genetic alterations could be related with tumor progression with a malignant transformation.

通过分析胶质母细胞瘤的基因表达和突变，探讨胶质母细胞瘤发生的特异性因素，特别是时间和空间特征。在可能与侵袭相关的整合素中，α 3亚基在肿瘤干细胞中具有显著较高的表达水平。整合素α 3亚基在肿瘤侵袭中可能起重要作用。此外，在肿瘤进展过程中，检测FAS和TP53突变。这些基因改变可能与肿瘤进展和恶性转化有关。

项目成果

Ependymoma and choroid plexus papilloma as synchronous multiple neuroepithelial tumor in the same patient : a case report and review of literature

室管膜瘤和脉络丛乳头状瘤同时发生在同一患者的多发性神经上皮肿瘤一例报告并文献复习

• 发表时间: 2010
• 期刊: Neurosurgery (in press)
• 作者: Hayashi Y.;et al
• 通讯作者: et al

Frequent single nucleotide polymorphism (SNP) of BCL10 and association with poor prognosis in primary intracranial germ cell tumors

BCL10 频繁的单核苷酸多态性 (SNP) 与原发性颅内生殖细胞肿瘤的不良预后相关

• 发表时间: 2009
• 作者: 林裕;渡邉卓也;中田光俊;喜多大輔;林康彦;内山尚之;濱田潤一郎
• 通讯作者: 濱田潤一郎

Secondary anaplastic astrocytomadeveloping in a young adult withautoimmune lymphoproliferativesyndrome(ALPS)

患有自身免疫性淋巴增殖综合征 (ALPS) 的年轻成人继发性间变性星形细胞瘤

• DOI: 10.1111/j.1365-2990.2010.01123.x
• 发表时间: 2011
• 期刊: Neuropathol ApplNeurobiol
• 作者: Kita;D.;Hayashi;Y.;Watanabe;T.;Korshunov;A.;von Deimling;A.;Nakada;M.;Kasahara;Y.;Zen;Y. and Hamada;J
• 通讯作者: J

A reevaluation of the primary diagnosis of hemangiopericytoma and the clinical importance of differential diagnosis from solitary fibrous tumor of the central nervous system

• DOI: 10.1016/j.clineuro.2008.07.010
• 发表时间: 2009-01-01
• 期刊: CLINICAL NEUROLOGY AND NEUROSURGERY
• 影响因子: 1.9
• 作者: Hayashi, Yutaka;Uchiyama, Naoyuki;Hamada, Jun-ichiro
• 通讯作者: Hamada, Jun-ichiro

巨大insular glioma摘出の問題点

巨大岛状胶质瘤摘除的问题

• 发表时间: 2010
• 作者: 林裕;中田光俊;喜多大輔;佐野宏樹;田中慎吾;長谷川貴之;林康彦;内山尚之;濱田潤一郎
• 通讯作者: 濱田潤一郎