Radiation Quality and Relative Biological Effectiveness of Proton Beams

质子束的辐射质量和相对生物有效性

• 批准号: 03454278
• 负责人: INADA Tetsuo
• 金额: $ 2.75万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03454278/
• 关键词: Radiation quality; LET; Mixed neutrons; Bragg peak; RBE; Dosimetry; Multi.cell spheroid; Cell inactivation; 陽子線照射野形成; エネルギー微調性; 減連形中性子線量計; がんの陽子線治療; 陽子線の線質; 生物効果比; 肺コロニ-形成法

Correlation of a wide range of published data from proton irradiation experiments on several biological materials has been achieved in terms of the radiation quality of proton beam and the precice end point of radiation effects.Linear energy transfer (LET) of proton beams at the spread out bragg peak (SOBP) has been evaluated for several quality factors such as the initial energies, the width and irradiation position of SOBP and the field shaping devices. For the quality specification of proton beam, the initial energy should be categorized into three classes, below 100MeV, 100-200 Mev and above 200 MeV.The standard irradiation position is suggested to be the middle of 4-5cm width SOBP.The contamination of secondary radiations including neutrons should be estimated. Comparative study on RBE of proton beams is suggested to carry out under such limited conditions. In addition, the end point of biological effects should be definite and the dosimetry in small animal should be made within 3% for the standard radiations such as ^<60>Co gamma rays or 3-4 MVX rays. For these careful limitations, RBE value of proton beams applied to the deep seated tumor therapy is obtainable from 1.0 to 1.2.

根据质子束的辐射质量和辐射效应的精确终点，对质子束辐照生物材料的大量实验数据进行了关联，并对质子束在展宽布拉格峰（SOBP）处的线性能量传递（LET）的初始能量、初始能量、初始能量和初始能量等几个质量因子进行了评价。SOBP的宽度和照射位置以及场整形装置。在质子束流质量指标中，初始能量应分为100 MeV以下、100-200 MeV和200 MeV以上三类，标准辐照位置建议为4-5cm宽SOBP的中部，应估算包括中子在内的次级辐射污染。建议在这样的限制条件下开展质子束RBE的比较研究。此外，对于标准辐射（如γ射线或MVX射线），生物学效应的终点应明确，小动物的剂量测定应控制在3%以内<60>。由于这些严格的限制，质子束用于深部肿瘤治疗的RBE值在1.0 ~ 1.2之间。

项目成果

T.Tnada,Y.Hayakawa J.Tada,Y.Takada,et al.: "Charactreistics of proton beams after field shaping at PMRC" Medical & Biological Engineering & Computing.

T.Tnada,Y.Hayakawa J.Tada,Y.Takada,et al.：“PMRC 场整形后质子束的特性” 医学

J.Tada et al.: "Neuron dose estimation of patients irradiated by proton beam for cancer treatment" Jpn.J.Med.Phys.13,2. 127-131 (1993)

J.Tada 等人：“用于癌症治疗的质子束照射患者的神经元剂量估计”Jpn.J.Med.Phys.13,2。

Hideo Tatsuzaki;Tetsuo Inada;et al.: "Eary Skin Reaction Following Superficial Proton Irradiation" Journal of Radiation Research. 32. 175-180 (1991)

Hideo Tatsuzaki；Tetsuo Inada；et al.：“浅表质子照射后的早期皮肤反应”辐射研究杂志。

Ken-ichi Hasegawa: "A Proton Profile Monitor Using on Amorphous Silicon Photodiode Array" IEEE Transaction on Nuclear Science. 40. 569-572 (1993)

Ken-ichi Hasekawa：“用于非晶硅光电二极管阵列的质子轮廓监测器”IEEE 核科学汇刊。

Nobuo Kubota: "The RBE of a high energy proton beam in monolayer cultures and multicellular spheroids of human tumor cells" Radiotherapy and Oncology. (発表予定).

Nobuo Kubota：“人类肿瘤细胞单层培养物和多细胞球体中高能质子束的 RBE”放射治疗和肿瘤学（即将发表）。