Integrated Treatment Planning System of Proton Therapy for Deeply Seated Tumors

深部肿瘤质子治疗综合治疗计划系统

• 批准号: 60480253
• 负责人: INADA Tetsuo
• 金额: $ 3.58万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480253/
• 关键词: Treatment planning system; Proton therapy; Isodose distribution; Bolus design; 3D display; Gated irradiation; Respiratory movement; 三次元表示; 呼吸性移動; 肺がん治療; 呼吸同調照射制御; 被曝線量低減; 散乱陽子線; ドキュメント・ファイル

A practical system of radiotherapy treatment planning has been developed for 250 MeV proton beam at PARMS. The system allows rapid display of isodose distribution and range compensator (bolus) design on CT image, according to the input of target volume and irradiation mode selection. The bolus fabrication can be done by either drill or milling machine numerically controlled by the design data.The recording and displaying functions of this treatment planning system were extended with the aid of 3D subprogram. The 2D input data of body contor, target volume, related organs and bolus shapes in several CT slices have been three-dimensionally displayed. These 3D images have made it possible to confirm and optimize the results of treatment planning.Respiratory gating was introduced to the irradiation of tumors affected by respiratory movement. A gate signal arbitrarily set on the respiratory curve triggers a microwave oscillator of a linear accelerator, which gives rise to intermittent irradiation. A phantom specially designed to simulate a lung cancer patient and low sensitivity film were used for verification. A mask for ventilation and an airbag for thoracoabdominal pressure were employed to detect excursion of the tumor both in the phantom stury and the airbag alone was used in the clinical application. The efficacy of this technique was satisfactorily proven. Gated irradiation can contribute to precise radiotherapy for tumors close to the diaphragm by eliminating the excursion of the tumors.

本文介绍了在PARMS上研制的250MeV质子束放射治疗计划实用系统。该系统可以根据靶区体积的输入和照射模式选择，在CT图像上快速显示等剂量分布和范围补偿器（团注）设计。根据设计数据，可在数控钻床或铣床上加工弹丸，并通过三维子程序扩展了治疗计划系统的记录和显示功能。在多个CT层面上，对人体轮廓、靶体积、相关器官和团注形状的二维输入数据进行了三维显示。这些3D图像使得确认和优化治疗计划的结果成为可能。呼吸门控被引入到受呼吸运动影响的肿瘤的照射中。在呼吸曲线上任意设置的门信号触发线性加速器的微波振荡器，这引起间歇照射。使用专门设计的模拟肺癌患者的体模和低灵敏度胶片进行验证。在体模中分别使用通气面罩和胸腹压气囊检测肿瘤的偏移，在临床应用中单独使用气囊。这项技术的功效得到了令人满意的证明。门控照射可以通过消除肿瘤的偏移而有助于对靠近横膈的肿瘤进行精确的放射治疗。

项目成果

大原潔,稲田哲雄,北川俊夫 他: 日本医学放射線学会雑誌. 47. 64-72 (1987)

Kiyoshi Ohara、Tetsuo Inada、Toshio Kitakawa 等：日本医学放射学会杂志 47. 64-72 (1987)。

稲田哲雄: 日本医学放射線学会雑誌. 45. 1047-1055 (1985)

Tetsuo Inada：日本医学放射学会杂志 45. 1047-1055 (1985)

Ohara, Kiyoshi et al.: "Irradiation Synchronized with Respiratory Cycle" Nippon Acta Radiologica. 47. 488-496 (1987)

Ohara、Kiyoshi 等人：“与呼吸周期同步的照射”Nippon Acta Radiologica。

Inada, Tetsuo: "Nuclear and Atomic Data for Radiotherapy and Relaled Radiobiology(Data Requirements in Present and Future Readiotherapy)" International Atomic Energy Agency, Vienna, 454(10) (1987)

Inada, Tetsuo：“放射治疗和相关放射生物学的核和原子数据（当前和未来放射治疗的数据要求）”国际原子能机构，维也纳，454(10) (1987)

Inada, Tetsuo et al.: International Atomic Energy Agency. "Data Requirements in present and Future Radiotherapy" in "Nuclear and Atomic Data for Radiotherapy and Related Radiobiology", 347-356 (1987)

Inada、Tetsuo 等人：国际原子能机构。