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Mechanisms of estrogen action to women with senile dementia-Alzheimer's type

雌激素对女性老年性痴呆阿尔茨海默氏症的作用机制

基本信息

批准号：
03454401
负责人：
HONJO Hideo
金额：
$ 2.05万
依托单位：
Kyoto Prefectural University of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03454401/
关键词：
Senile demetia-Alzheimer's type Estrogen Estrone sulfate Central Nervous System Basal nucleus Glia Mechanism of action Disturbance of memory エストロンサルフェート記憶障害アルツハイマ-型老年痴呆中枢神経アセチルコリン神経培養 SteroidーSulfatase mRNA 分子生物学

项目摘要

Previously, we gave a conjugated estrogen (1.25mg/day,6 weeks) to seven women suffering from senile dementia-Alzheimer's type. Thir symptoms improved significantly (1989.J.Steroid Biochem 34;521). In the present study, we investigated fundamental researches to clarify the mechanism of estrogen.A. Estrogen as a growth factor to central nervous cells.Rat fetal diagonal band tissue containing cholinergic neurons was grafted into the anterior eye chamber of adult female rats that had either been treated or not with 2mg estradiol valerate injected every 3 days after oophorecfomy. The estrogen treatment promoted development of acetylcholinesterase-positive basal forebraims neurous. Thus,estrogen may act on chorinergic neurons as a growth factor (1992 J.Steroid Biochem Mole Biol 41;633).B.Estrogen effect go Glia Glia cell was cultured selectively from the hypothalamus of mouse, 1-2 days after delivery. Addition of estrone sulfate into the incubation increased percentage of stellate type glia which was thought as more developed type. In vivo estrogen may increase developed astroglias which help the function of neurons,(J.Japanese medical association for colimacterium,accepted).C. A preliminaly study with molecular biological technique. The study was reported in J.Kyoto Pret Univ Med 102;153,1993.

在此之前，我们给了7名患有老年痴呆-阿尔茨海默氏型的妇女结合雌激素（1.25mg/天，6周）。症状明显改善（1989.J.SteroidBiochem 34;521）。本研究通过基础研究来阐明雌激素的作用机制。雌激素作为中枢神经细胞的生长因子将含有胆碱能神经元的大鼠胎儿斜角带组织移植到成年雌性大鼠的前房中，这些大鼠在卵巢切除后每3天注射2 mg戊酸雌二醇。雌激素处理促进乙酰胆碱酯酶阳性基底前脑神经元的发育。因此，雌激素可以作为生长因子作用于胆碱能神经元（1992年，J.SteroidBiochemMoleBiol41;633）.B.雌激素作用于神经胶质细胞在分娩后1-2天，从小鼠下丘脑选择性培养神经胶质细胞。加入硫酸雌酮可增加星形胶质细胞的比例，认为星形胶质细胞是较发达的类型。体内雌激素可增加发育的星形胶质细胞，这有助于神经元的功能（J.日本肠杆菌医学协会，接受）。分子生物学技术的初步研究。该研究报道于J.京都普雷特大学医学102; 153，1993。