Gas composition in the middle ear cavity

中耳腔内的气体成分

• 批准号: 03454403
• 负责人: OKUBO Jin
• 金额: $ 4.03万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03454403/
• 关键词: ME.gas composition (ME : middle ear); ME.respiration; mucous metabolism; 酸素分圧; 粘膜ガス代謝; 炭素ガス分圧

The gas composition in the middle ear cavity in patients with perforated tympanic membrane and in normal subjects was analyzed by mass spectrometry.Results revealed that the middle ear gas composition in normal subjexts was ; nitrogen ; 83.7% , oxygen ; 9.2% , and CO_2 ; 6.2% (The partial pressure of the various gases was expressed as a percentage of 713 mmHg).The partial pressure of oxygen in the middle ear cavity with perforated tympanic membrane is expected to be higher than in the normal state because of diffusion of atmospheric gas into the middle ear cavity.The mechanism by which the gaseous pressure in the middle ear is maintained at 1 ATA under an environment of atmospheric pressure is dependent on the metabolism of the gases that are produced in the mucous membranes of the middle ear cavity.Gas metabolism in the middle ear also plays an important role in sound conduction. In addition, the low partial pressure of oxygen in the middle ear cavity results in a micro-aerophilic bacterium air condition.The microaerophilic air space in the middle ear acts as a physiological barrier against bacterial infection.

用质谱仪对鼓膜穿孔患者和正常人中耳腔气体成分进行了分析，结果表明，正常人中耳气体成分为：氮气，83.7%，氧气，9.2%，CO_2；6.2%(各种气体的分压以713毫米汞柱的百分比表示)。鼓膜穿孔的中耳腔内的氧分压预计会高于正常状态，因为大气气体扩散到中耳腔内。在大气压环境下，中耳内气体压力保持在1atA的机制依赖于中耳腔粘膜中产生的气体的新陈代谢。中耳的气体代谢在声传导中也起着重要作用。此外，中耳腔中氧气的低分压导致了微嗜氧菌的空调。中耳中的微嗜氧性空气空间起到了抵抗细菌感染的生理屏障的作用。

项目成果

大久保 仁: "耳圧外傷の診断と治療" 頭頚部外科誌. 3. 3-9 (1993)

大久保仁 (Hitoshi Okubo)：“耳气压伤的诊断和治疗”，《头颈外科杂志》，3. 3-9 (1993)。

大久保仁: "大気圧環境の中耳腔能動換気について" 耳鼻咽喉科展望. 36. 251-270 (1993)

大久保仁 (Hitoshi Okubo)：“论大气压环境下中耳腔的主动通气”《耳鼻喉科观点》36. 251-270 (1993)。

OKUBO Jin: "Diagnosis and treatment of the barotrauma (Barotrauma in SCUBA diving)" J.Jpana Society Head Neck Surgery. 3. 3-9 (1993)

OKUBO Jin：“气压伤（水肺潜水中的气压伤）的诊断和治疗”J.Jpana Society Head Neck Survival。

大久保 仁: "大気圧環境の中耳腔能動換気について" 耳鼻咽喉科展望. 36. 251-270 (1993)

大久保仁 (Hitoshi Okubo)：“论大气压环境下中耳腔的主动通气”《耳鼻喉科观点》36. 251-270 (1993)。

大久保 仁: "スキュ-バダイビングのための空洞圧外傷の知識と理解.後編:空洞臓器の気圧外傷と耳抜きの知識" 臨床スポ-ツ. 8. 917-929 (1991)

Hitoshi Okubo：“水肺潜水的空洞气压伤的知识和理解。第 2 部分：空洞器官气压伤和耳朵切除的知识”《临床运动》8. 917-929 (1991)。