权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Basic research on physiology and pathophysiology of the Eustachian tube function

咽鼓管功能的生理学和病理生理学基础研究

基本信息

批准号：
60480378
负责人：
OKUBO Jin
金额：
$ 0.96万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1987
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480378/
关键词：
Sonotubometric test po_2 tension in middle ear Eustachian tube function Mastoid cavity 中耳Gas代謝鼓室【PO_2】滲出性中耳炎

项目摘要

Aiming at few researches for thr function and pathogenesis of auditory tube dysfunction diseases, we have continued to study the development of a sonotubometer with our study thesis No. 57870102. In the present study, we proceeded to the next step to study gas metabolism and auditory tube function in the middle ear cavity. In general, the auditory tube bulonging to the middle ear cavity has been explained like an organ to enspire the air under the emvironmental pressure into the middle cavity from outside. However, several loads added while measuring CO_2 in the middle ear cavity mad us understand the air not supplied into the middle ear cavity from the auditory tube completely by opening and closing of the auditory tube in association with deglutition movement in the environment under the ordinary pressure, the existence of specific cavernous gas metabilism as a cavernous properity in the middle ear cavity, and the auditory tube haveing a role to expire it into the outside.1) It was u … More nderstood that po_2 values in the middle ear cavity in normal adults were about 53 mmhg equivalent to about 1/2 of the atomosphere.2) po_2 in the middle ear cavity showed no changes by opening and closing of the auditory tube in association with wsallowing movement.3) It was shown after fixiation of a sensor in the tympanic bulla in the guinea pigs that hte gas was not flowed into the middle ear cavity even after swallowing movements by covering their head with 100% oxygen but gas exchange via the auditory tube existed in the case of a difference in the atomospheric pressure caused by rise of po_2 in the middle ear cavity after swallowing movements by increasing the oxyten pressure to about 100 mmH_2o.4) PO_2 values showed no changes but the pressure in the middle ear cavity was increased when po_2 was determined in humans while sleeping, which was considered to be caused by CO_2 diffusion. The pressure in the middle earcavity was recovered to the normal pressure when deglutition movements occurred.In conclusion, there is a tendency of normal auditory tube function simply to heighten the gaseous pressure in the middle ear cavity due to closed auditory tube at rest, in which the auditory tube is opened by deglutition movements to expire it into the atomosphere. In other words, a phenomenon to heighten the pressure in the middle ear cavity cannot be grasped owing to opened auditory tube by deglutition movements at awakening but the middle ear cavity has specific gas metabolism by heightened pressure in the middle ear cavity at slooe, etc. so that the auditory tube exists as its discharging tube. Less

针对目前对咽鼓管功能障碍性疾病的功能和发病机制研究较少的情况，我们继续研究了声管仪的开发，研究论文号为57870102。在本研究中，我们继续下一步研究中耳腔中的气体代谢和咽鼓管功能。一般认为，外耳道与中耳腔相通，就像一个器官，在精神压力的作用下，将空气从外部吸入中耳腔。而在中耳腔测定CO_2时增加的几个负荷使我们认识到在常压环境下伴随吞咽运动的咽鼓管的开闭并不能完全将空气从咽鼓管供应到中耳腔中，中耳腔中存在着作为一种海绵性质的特定的海绵状气体代谢，和听觉管有一个作用，它的呼气到外面。1）这是使用 ...更多信息结果表明：正常人中耳腔的PO_2值约为53 mmHg，相当于大气层的1/2; 2）中耳腔的PO_2值不随咽鼓管的开闭而变化。将传感器固定在豚鼠的鼓泡中后显示，即使在吞咽运动后，气体也不会流入中耳腔，在吞咽运动后，将氧分压提高到100 mmH_2O左右，使中耳腔PO_2升高，造成气压差时，用100%氧气覆盖头部，但通过咽鼓管进行气体交换。2在人睡眠时测定，认为是CO_2扩散所致。结论：咽鼓管功能正常的趋势是咽鼓管在静止时关闭，咽鼓管在吞咽运动时打开，使咽鼓管内的气体压力升高，从而使咽鼓管内的气体压力恢复到正常水平。换句话说，由于在觉醒时吞咽运动打开的咽鼓管，不能掌握中耳腔中压力升高的现象，但是中耳腔具有特定的气体代谢，这是由于在睡眠时中耳腔中的压力升高等，使得咽鼓管作为其放电管而存在。少