Neiuromagnetic study on speech sound processing in human auditory cortex

人类听觉皮层语音处理的神经磁学研究

• 批准号: 03455002
• 负责人: KURIKI Shinya
• 金额: $ 2.69万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03455002/
• 关键词: Neuromagnetic Field; SQUID; Auditory Cortex; Voice Processing; Auditory Evoked Field

We have been studied the neural activities in the human auditory cortex concerning with the speech sound processing by measuring neuromagnetic fields. Obtained results are summarized as follows.1. Background noises in the auditory evoked magnetic field responses recorded with a 37 channel SQUID magnetometer have been studied. The background noise was found to have a main contribution from the spontaneous fields, which originate in the neural activities of the brain. The spontaneous fields had strong spatial correlation across the recording sites even after averaging over 100 epochs. Furthermore, the signal to noise ratio, which is needed for accurate source localization, was determined from the experiments.2. The relationship between tinnitus and auditory neural activities was studied based on the neuromagnetic fields. It was found that either Nlm or Plm component increases due to the suppression of tinnitus by electrical stimulation to cochlea under some circumstances.3. Neuromagnetic fields evoked by monosyllable speech sounds, i.e. /a/, /ka/, /ha/ and /na/, have been measured using a 37 channel SQUID magnetometer. Parameters of a dipole current source have been estimated using several sets of field data recorded in different measurement runs. It was found from the results that statio-temporal movements of the sources depend on the subjects as well as stimuli. However, the sources of N1m components evoked by /a/ and /na/ commonly move either to anterior, medial or posterior direction in all subjects.

本文用神经磁场测量方法研究了人类听觉皮层与语音处理有关的神经活动。所得结果总结如下.本文研究了37通道SQUID磁感应强度计记录的听觉诱发磁场反应中的背景噪声。背景噪声被发现具有来自自发场的主要贡献，自发场起源于大脑的神经活动。即使在平均超过100个历元之后，自发场在记录站点上也具有很强的空间相关性。此外，通过实验确定了精确定位所需的信噪比.从神经磁场的角度探讨耳鸣与听觉神经活动的关系。研究发现，在某些情况下，电刺激耳蜗抑制耳鸣，导致Nlm或Plm成分增加.用37通道SQUID磁强计测量了单音节语音（即/a/、/ka/、/ha/和/na/）诱发的神经磁场。偶极电流源的参数已估计使用几组现场数据记录在不同的测量运行。结果发现，源的静态-时间运动依赖于被试以及刺激。然而，/a/和/na/诱发的N1 m成分的来源通常在所有受试者中向前、内侧或向后移动。

项目成果

竹内 文也,栗城 真也: "誘発脳磁図の計測と電源推定" 日本ME学会誌. 6. 28-43 (1992)

Fumiya Takeuchi、Shinya Kuriki：“诱发脑磁图的测量和功率源的估计”日本 ME 学会杂志 6. 28-43 (1992)。

T.Kobayashi,M.Ii and S.Kuriki: "Analysys of neuromagnetic fields generated by a current dipole Source" Applied Electromagnetics in Materials and Computational Technology ed.,t.Honma et al.,Hokkaido univ.Press.13-16 (1992)

T.Kobayashi，M.Ii 和 S.Kuriki：“电流偶极源产生的神经磁场的分析”应用电磁学材料和计算技术编辑，t.Honma 等人，北海道大学 Press.13-16（

栗城 真也,竹内 文也: "脳磁図ー聴覚誘発反応を中心としてー" nanoGIGA. 1. 513-515 (1992)

Shinya Kuriki、Fumiya Takeuchi：“脑磁图 - 关注听觉诱发反应”nanoGIGA。 1. 513-515 (1992)

S.Kuriki: "Localization of cortical neuromagnetic sources of auditory evoked responses to short speech sounds" Biomed. Res.Vol.13, Suppl.1. 39-43 (1992)

S.Kuriki：“对短语音的听觉诱发反应的皮质神经磁源的定位”Biomed。

F.Takeuchi, M.Mukai, S.Kuriki, M.Hayashi and T.Imada: "Spatio-temporal source localization of neuromagnetic fields evoked by pure tones" Biomagnetism: Clinical Aspects, ed. by M.Hoke et al. Elsevier. 181-184 (1992)

F.Takeuchi、M.Mukai、S.Kuriki、M.Hayashi 和 T.Imada：“纯音引起的神经磁场的时空源定位”生物磁学：临床方面，编辑。