Antitumor Precious Metal Complexes and their Interaction with Biollogically Related Moleale

抗肿瘤贵金属配合物及其与生物相关分子的相互作用

• 批准号: 04453043
• 负责人: MIYAMOTO Takeshi
• 金额: $ 4.16万
• 依托单位: Kitasato University (1994)The University of Tokyo (1992-1993)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04453043/
• 关键词: Platinum Complexes; Water-Solubll Complexes; Phosphane; Arsane; Stibane; Hydroxy Complexes; シスプラチン; 生体分子; 溶液平衡; 15族ドナー; 核酸

The aqueous chemistry of platinum (II) complexes with phosphorus, arsenic and antimonious donors are still scanty and undeveloped whereas that of the am (m) ine complexes are well known as exemplified in spasmodic reports of cisplatin. A series of new water soluble platinum (II) complexes stabilized with trimenthylphosphane, trimethylarsane or trimethylstibane were synthesized for the first time by the elegant use of the anion-exchange resin. Their cystal structures were determined by X-ray diffration method. The solution equilibria among these complexes were investigated by ^1H.^<13>C,^<31>P or ^<195>pt NMR spectrscopy. Acid base equilibria among cis- [Pt (OH) _2 (AMe_3) _2], cis- [Pt (OH) (AMe_3) _2]_2^<2+> and cis- [Pt (OH_2) _2 (AMe_3) _2]^<2+> (where A=PMe_3, AsMe_3 or SbMe_3) were well established.Dihydroxide complex, cis- [Pt (OH) _2 (AMe_3) _2]・nH_2O affords several water soluble complexes in a quantitative yield by the simple reaction with free acid, e.g., oxalic acid or CO_2. This demonstrates that new hydroxides are potentially good material for the preparation of many water-soluble complexes. In near future, the interaction between the hydroxide and a biologically related molecule (ascorbic acid or nucleic acid) will be surveyed.

铂（II）配合物与磷、砷和锑供体的水化学研究仍然很少和不发达，而胺(m)配合物的水化学研究则众所周知，如顺铂的间歇性报道。利用阴离子交换树脂，首次合成了一系列以三甲基膦、三甲基胂或三甲基苯甲酸稳定的新型水溶性铂配合物。用x射线衍射法测定了它们的晶体结构。用^1H研究了这些配合物的溶液平衡。^<13>C,^<31>P或^<195>pt核磁共振光谱。建立了顺式- [Pt (OH) _2 (AMe_3) _2]、顺式- [Pt (OH) (AMe_3) _2]_2^<2+>和顺式- [Pt (OH_2) _2 (AMe_3) _2]^<2+>（其中A=PMe_3、AsMe_3或SbMe_3）之间的酸碱平衡。顺式二氢氧配合物[Pt (OH) _2 (AMe_3) _2]·nH_2O通过与游离酸（如草酸或CO_2）的简单反应，可以定量地得到几种水溶性配合物。这表明新的氢氧化物是制备许多水溶性配合物的潜在良好材料。在不久的将来，氢氧化物与生物相关分子（抗坏血酸或核酸）之间的相互作用将被研究。

项目成果

T.K.Miyamoto: "A New Seris of Water-Soluble Platinum(II)Complexes Stabilized with Trimethylarsane.Their Synthesis,Crystal Structures,and Solution Equilibria." Chem Lett.1994. 1971-1974 (1994)

T.K.Miyamoto：“用三甲基胂稳定的新型水溶性铂 (II) 配合物系列。它们的合成、晶体结构和溶液平衡。”

鈴木善継: "(Oxalato-О,О′)bis(trimethylphosphine)platinum(II)." Acta Cryst.C49. 1317-1318 (1993)

Yoshitsugu Suzuki：“(Oxalato-О,О′)双(三甲基膦)铂(II)。Acta Cryst.C49 1317-1318 (1993)。

高木 繁: "Syntheses and Spectral Studies Metal-Metal Bonds Extended over a Porphyrin Ring III.New Metal-Metal bonded Indium Porphyrin Complexes,(tbpp)In-ML and (5fp)In-ML." J.Organomet.Chem.429. 287-299 (1992)

Shigeru Takagi：“在卟啉环 III 上延伸的金属-金属键的合成和光谱研究。新型金属-金属键合的铟卟啉配合物，(tbpp)In-ML 和 (5fp)In-ML。J.Organomet.Chem.429” 287-299（1992）

T.K.Miyamoto,Y.Suzuki and H.Ichida: "The Stability and Reactivity of Dihydroxy Bis(trimethylphosphine)platinum(II)." Chem.Lett.1992. 839-842 (1992)

T.K.Miyamoto、Y.Suzuki 和 H.Ich​​ida：“二羟基双（三甲基膦）铂 (II) 的稳定性和反应性。”

T.K.Miyamoto,Y.Suzuki and H.Ichida: "Stability and Reactivity of Dihydroxobis(trimethylphosphine)platinum(II),an Intermediate Species for the Synthesis of a Variety of Water-Soluble Phosphine Complexes." Bull.Chem.Soc.Jpn.65. 3386-3397 (1992)

T.K.Miyamoto、Y.Suzuki 和 H.Ich​​ida：“二羟基双（三甲基膦）铂（II）的稳定性和反应性，一种用于合成各种水溶性膦配合物的中间体。”