Shh-Ang-Tie2: A new therapeutic target for ocular angiogenesis.

眼部新生血管可见于各种疾病，如伤口愈合、缺血、老年性黄斑变性等。严重的眼部新生血管可导致视力丧失。抗血管内皮生长因子药物有时用于AMD。但在另一种情况下，我们还没有有效的方法来治疗眼部新生血管。血管生成素是Shh信号诱导的血管生成因子之一。在激光诱导的大鼠脉络膜新生血管模型中，Shh相关的信号转导分子Shh和Gli3在激光光斑周围的视网膜色素上皮和视网膜呈免疫组织化学阳性反应。Shh可能通过Ang的表达在脉络膜新生血管中发挥重要作用。结膜注射Shh抑制剂环丙胺可抑制脉络膜新生血管形成。Shh可能是治疗眼部新生血管的有效靶点。

Ocular neovascularization occurs in various diseases like wound healing, ischemic, age related macular degeneration, etc. Sever ocular neovascularization cases visual loss. Anti VEGF drugs are sometimes used for AMD. But in the other desease, we have no effective method to treat the ocular neovasclarizaiton. Angiopoietin is one of the angiogenic factors that are induced by Shh signals. In the laser induced choriodal neovasucularizaiton model in rat, Shh and Gli3, the Shh related signal trunsducion molecule, were immunohistochemically positive in the retinal pigment epithelium and retina around the laser spot. Shh may have an important role in the choroidal neovascularization via Ang expression. And conjunctibal injection of cyclopamin, Shh inhibitor, suppressed the choroidal neovasucularization. Shh may be aneffective target to treat the ocular neovascularization.