Development, Design and Evaluation of Novel Natural and Synthetic Antioxidants

新型天然和合成抗氧化剂的开发、设计和评价

• 批准号: 04453084
• 负责人: NIKI Etsuo
• 金额: $ 3.9万
• 依托单位: University of Tokyo, Research Center for Advanced Science and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04453084/
• 关键词: Lipid peroxidation; Antioxidant; Vitamin E; Phenols; Carbazoles; Selen compounds; Atherosclerosis; 酸化; 自動酸化; 抗酸化剤; フェノール; エブセレン; カルバゾール; 低比重リポタンパク

This study has been carried out aiming at the development, design and evaluation of novel natural and synthetic antioxidants which effectively inhibit the oxidative deterioration of biological molecules, membranes and tissues as well as foods and oil products. Following results were obtained.1. The antioxidant activities of vitamin E, phenolic compounds and carbazoles were evaluated quantitatively and it was shown that physical factors such as mobility at the microenvironment as well as chemical reactivities are quite important in determining overall antioxidant potency.2. Inhibition of oxidation of low density lipoprotein, which is an important initial event of atherosclerosis, by antioxidant was studied in detail.3. Inhibition of oxidation of lipids by various phenols, aminophenols and carbazoles was studied and the correlation between structure and chemical reactivity was discussed.4. The kinetics of mechanisms of antioxidation by selenium containing novel compound was studied.5. Action of metal chelating agents was found to depend on metal, but not on lipids.

本研究旨在开发、设计和评价新型天然和合成抗氧化剂，有效抑制生物分子、膜和组织以及食品和油脂产品的氧化变质。主要研究结果如下：1.对维生素E、酚类化合物和咔唑类化合物的抗氧化活性进行了定量评价，结果表明，物理因素如在微环境中的流动性以及化学反应性在决定整体抗氧化能力方面是非常重要的.详细研究了抗氧化剂对动脉粥样硬化重要起始事件低密度脂蛋白氧化的抑制作用.研究了各种酚类、氨基酚类和咔唑类化合物对油脂氧化的抑制作用，并讨论了结构与化学反应活性之间的关系.对含硒化合物的抗氧化机理进行了动力学研究.发现金属螯合剂的作用依赖于金属，但不依赖于脂质。

项目成果

E.Komuro, Y.Yamamoto, E.Niki: "Inhibition of lipid peroxidations by antioxidant biofactors made from cereals, oil seeds and other foodstuffs" Vitamin. 67. 481-484 (1993)

E.Komuro、Y.Yamamoto、E.Niki：“由谷物、油籽和其他食品制成的抗氧化剂生物因子抑制脂质过氧化”维生素。

E.Niki: "Supplement E:The chemistry of hydroxyl,ether and peroxide groups" John Wiley & Sons,ed.by G.Scott, 1250 (1993)

E.Niki：“补充 E：羟基、醚和过氧化物基团的化学” John Wiley

M.Kigoshi, K.Sato and E.Niki: "Oxidations of lipids induced by Dioctadecyl Hyponitrite and Di-t-butyl Hyponitrite in organic solution and aqueous dispersions. Effect of reaction medium and size of radicals on efficiency of chain initiation" Bull Chem.Soc.

M.Kigoshi、K.Sato 和 E.Niki：“有机溶液和水分散体中由次亚硝酸二十八烷基酯和次亚硝酸二叔丁酯诱导的脂质氧化。反应介质和自由基大小对链引发效率的影响”Bull Chem

M.Iwatsuki,E.Niki,S.Kato,K.Nishikori: "Antioxidant activities of -tocopherol and hydroxycarbozole against lipid peroxidation in homogeneous solution and in liposomal membranes." Chem.Lett.1735-1738 (1992)

M.Iwatsuki、E.Niki、S.Kato、K.Nishikori：“α-生育酚和羟基咔唑对均匀溶液和脂质体膜中脂质过氧化的抗氧化活性。”

E.Niki,M.Matsuo (L.Packer,J.Fuchs,eds.): "Vitamin E in Health and Disease" Marcel Dekker,New York, (1992)

E.Niki,M.Matsuo（L.Packer、J.Fuchs 编辑）：“健康与疾病中的维生素 E”Marcel Dekker，纽约，（1992 年）