A New Evaluation for the Health Effect Induced by Occupational Exposure to Lead
A New Evaluation for the Health Effect Induced by Occupational Exposure to Lead
批准号:
04454218
负责人:
TOMOKUNI Katsumaro
金额:
$3.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (B)
财政年份:
1992
资助国家:
日本
项目状态:
已结题
起止时间:
1992 至 1993
中文摘要
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英文摘要
To investigate the new biological markers for evaluating the health effects by occupational exposure to lead, we determined urinary concentration of beta-aminoisobutyric acid (AIBA) which was a normal degradation product of thymine, and the concentration of delta-aminolevulinic acid (ALA) in urine and plasma. The urinary excretion of AIBA was increased with increasing exposure to lead. The determination of urinary AIBA in lead workers, therefore, may offer a new approach for evaluating the health effect of lead.In addition, the determination of plasma ALA, as well as urinary ALA, in lead workers was very useful for the biological monitoring of health effect by lead.
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K.Tomokuni: "High-sensitive determination of delta-aminolevulinic acid in serum or plasma" Porphyrins. 1. 299-304 (1992)
K.Tomokuni:“高灵敏度测定血清或血浆中的 δ-氨基乙酰丙酸”卟啉。
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K.Tomokuni: "Measurement of urinary delta-aminolevulinic acid by fluorometric HPLC and colorimetric methods" Ind Health. 30. 119-128 (1992)
K.Tomokuni:“通过荧光 HPLC 和比色法测量尿 δ-氨基乙酰丙酸”Ind Health。
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K.Tomokuni: "Interrelation between urinary delta-aminolevulinic acid(ALA), serum ALA, and blood lead in workers exposed" Ind Health. 31. 51-57 (1993)
K.Tomokuni:“暴露工人的尿 δ-氨基乙酰丙酸 (ALA)、血清 ALA 和血铅之间的相互关系”Ind Health。
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K.Tomokuni: "Relation between urinary beta-aminoisobutyric acid excretion and concentration of lead in blood of workers occupationally exposed to lead." Brit. J.Ind. Med.49. 365-368 (1992)
K.Tomokuni:“职业接触铅的工人的尿 β-氨基异丁酸排泄量与血液中铅浓度之间的关系。”
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K.Tomokuni: "HPLC micro-method for determining delta-aminolevulinic acid in plasma" Clin Chem. 39. 169-170 (1993)
K.Tomokuni:“测定血浆中 δ-氨基乙酰丙酸的 HPLC 微量方法”Clin Chem。
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共 17 条
Molecular-epidemiological studies on the risk evaluation of cancer induced by environmental carcinogen
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项目类别:Grant-in-Aid for Scientific Research (B)
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财政年份:2000
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依托单位:
Studies on the evaluation of health effects caused by toxic substances containing lead
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New indicators useful for biological monitoring of organic solvent and lead exposures
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财政年份:1995
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依托单位:
Relation between porphyrin-metabolic disorders and some internal factors in lead-exposed subjects
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批准号:07457096
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.67万
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财政年份:1995
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负责人:TOMOKUNI Katsumaro
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Studies on Abnormality of Porphyrin Metabolism Induced by Lead
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批准号:01480200
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.88万
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财政年份:1989
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负责人:TOMOKUNI Katsumaro
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依托单位:
Studies on the Modifications of Some Screening Methods for Health Examination in Lead Workers
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.09万
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财政年份:1985
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负责人:TOMOKUNI Katsumaro
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依托单位: